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Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

2007, Number 6

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Rev Invest Clin 2007; 59 (6)

Toll-like receptor in lung response to pathogens

Rivas-Santiago B, Juárez E

Language: Spanish
References: 69
Page: 481-488
PDF size: 108.63 Kb.


ABSTRACT

Innate immunity plays a central role in antimicrobial defense. Advances in the understanding of pathogen recognition systems of innate cells have yielded the identification of Toll like receptors (TLR) as key elements of the lung defense mechanisms which is heavily exposed to a variety of stimuli. TLR recognition of several microbial compounds induces proinflammatory cytokines production whose contribution to the host may be either protective or detrimental. Human immune response diversity may explain the differences observed between patients facing bacterial, viral and fungal lung infections. New strategies designs that modify innate immune response may be useful to limit detrimental consequences of inflammatory processes in the lung.


REFERENCES

  1. Martin TR, Frevert CW. Innate immunity in the lungs. Proc Am Thorac Soc 2005; 2: 403-11.

  2. Schurr JR, Young E, Byrne P, Steele C, Shellito JE, Kolls JK. Central role of toll-like receptor 4 signalling host defense in experimental pneumonia caused by gram-negative bacteria. Infect Immun 2005; 73(1): 532-45.

  3. Parilla NW, Hughes VS, Lierl KM, Wong HR, Page K. CpG DNA modulates interleukin 1β-induced expression in human bronchial epithelial (16HBE14o-) cells. Resp Res 2006; 7: 84.

  4. Brain JD. Mechanisms, measurement, significance of lung macrophage function. Envir Health Perspectives 1992; 97: 5-10.

  5. Stein D, Roth S, Vogelsang E, Nusslein-Volhard C. The polarity of dorsoventral axis in the drosophila embryo is defined by an extracellular signal. Cell 1991; 65: 725-35.

  6. Lemaitre B, Nicolas E, Micheaut L, Reichart JM, Hoffmann JA. The dorsoventral gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 1996; 86: 973-83.

  7. Medzhitov R, Preston-Hulburt P, Janeway CA Jr. A human homologue of the drosophila Toll protein signals activation of adaptative immunity. Nature 1997; 388: 394-7.

  8. Roach JC, Glusman G, Rowen L, Kaur A, Purcell MK, Smith KD, et al. The evolution of vertebrate toll-like receptors. Proc Natl Acad Sci 2005; 102: 9577-82.

  9. Ritter M, Mennerich D, Weith A, Seither P. Characterization of toll-like receptors in primary lung epithelial cells: strong impact of the TLR3 ligand poly (I:C) on the regulation of Tolllike receptors, adaptor proteins and inflammatory response. J Inflammation 2005; 2:16.

  10. Purcell MK, Smith KD, Hood L, Winton JR, Roach JC. Conservation of toll-like receptor signaling pathways in teleost fish. Comp Biochem Physiol Part D Genomics Proteomics 2006; 1: 77-88.

  11. Kaisho T, Akira S. Toll-like receptor function and signaling. J Allergy Clin ImmunoL 2006; 117: 979-87.

  12. Yamada H, Odonnell MA, Matsumoto T, Luo Y. Interferon -γ up-regulates toll-like receptor 4 and cooperates with lipopolysaccharide to produce macrophage derived chemokine and interferon-γ inducible protein 10 in human bladder cancer cell line RT4. J Urol 2005; 174: 1119-23.

  13. Power CP, Wang JH, Manning B, Kell MR, Aherne NF, Wu QD, Redmond HP. Bacterial lipoprotein delays apoptosis in human neutrophils through inhibition of caspase-3 activity: regulatory roles for CD14 and TLR-2. J Immunol 2005 173: 5229-37.

  14. Visintin A, Mazzoni A, Spitzer JH, Wyllie DH, Dower SK, Segal DM. Regulation of toll-like receptors in human monocytes and dendritic cells. J Immunol 2001; 166: 249-55.

  15. Krug A, Towarowski A, Britsch S, Rothenfusser S, Hornung V, Bals R, et al. Toll-like receptor expression reveals CpG DNA as unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL- 12. Eur J immunol 2001; 31: 3026-37.

  16. Iwasaki A, Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nat Immunol 2004; 5: 987-95.

  17. He B, Qiao X, Cerutti A. CpG DNA induces IgG class switch DNA recombination by activating human B cells through an innate pathway that requires TLR9 and cooperates with IL-10. J Immunol 2004; 173: 4479-91.

  18. MacRedmond R, Greene C, Taggart CC, McElvaney N, O’Neill S. Respiratory epithelial cells requires toll-like receptor 4 for induction of human β-defensin 2 by lipopolysaccharide. Resp Res 2005; 6: 116.

  19. Hertz CJ, Wu Q, Porter EM, Zhan YJ, Weismuller KH, Godowski PJ, et al. Activation of toll-like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human β defensin-2. J Immunol 2003; 171: 6820-6.

  20. Haase R, Kirsching CJ, Sing A, Schrottner P, Fukase K, Kusumoto S, et al. A dominant role of toll-like receptor 4 in the signaling of apoptosis in bacteria-faced macrophages. J Immunol 2003; 171: 4294-303.

  21. Power CP, Wang JH, Manning B, Kell MR, Aherne NF, Wu QD, Redmond HP. Bacterial lipoprotein delays apoptosis in human neutrophils through inhibition of caspase-3 activity: regulatory roles for CD14 and TLR-2. J Immunol 2003; 173: 5229-37.

  22. Thoma-Uszynski S, Stenger S, Takeuchi O. Induction of direct antimicrobial activity through mammalian toll-like receptors. Science 2001; 291: 1544.

  23. Wieland CW, Knapp S, Florquin S, de Vos AF, Takeda K, Akira S, et al. Non-mannose-capped lipoarabinomannan induces lung inflammation via toll-like receptor 2. Am J Respir Crit Care Med 2004; 170: 1367-74.

  24. Hirschfeld M, Weis JJ, Toshchakov V, Salkowski CA, Cody MJ, Ward DC, et al. Signaling by toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages. Infect Immun 2001; 69: 1477-82.

  25. Nishimura M, Naito S. Tissue-specific mRNA expression profiles of human toll-like receptors and related genes. Biol Pharm Bull 2005; 28: 886-92.

  26. Droeman D, Goldman T, Branscheid D, Clark R, Dalhoff K, Zabel P, Vollmer E. Toll-like receptor 2 is expressed by alveolar epithelial cells type II and macrophages in the human lung. Histochem Cell Biol 2003; 119: 103-8.

  27. Guillot L, Balloy V, McCormack FX, Golenbock DT, Chignard M, Si-Tahar M. The immunostimulatory activity of the lung surfactant protein A involves Toll-like receptor 4. J Immunol 2002; 168: 5989-92.

  28. Smiley ST, King JA, Hancock WW. Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4. J Immunol 2001; 167: 2887-94.

  29. Barness KA, Arcaroli J, Harken AH, Abraham E, Banerjee A, Reznikov L, McIntyre. Hemorrhage-induced acute lung injury is TLR4 dependent. Am J Physiol Regul Integr Comp Physiol 2004; 287: 592-9.

  30. Kaufmann A, Musset B, Limberg SH, Renigunta V, Sus R, Dalpke AH, et al. “Host tissue damage” signal ATP promotes nondirectional migration and negatively regulates toll-like receptor signaling in human monocytes. J Biol Chem 2005; 280: 32459-67.

  31. Hanley PJ, Musset B, Renigunta V, Limberg SH, Dalpke AH, Sus R, et al. Extracellular ATP induces oscillations of intracellular Ca2+ and membrane potential and promotes transciption of IL6 in macrophages. Proc Natl Acad Sci 2004; 101: 9479- 84.

  32. Pons J, Sauleda J, Regueiro V, Santos C, López M, Ferrer J, et al. Expression of Toll-like receptor 2 is up-regulated in monocytes from patients with chronic obstructive pulmonary disease. Resp Res 2006; 7: 64.

  33. Droemann D, Goldmann T, Tiedje T, Zabel P, Dalhoff K, Schaaf B. Toll-like receptor expression is decreased on alveolar macrophages in cigarette smokers and COPD patients. Resp Res 2006; 6: 68.

  34. Karimi K, Sarir H, Mortaz E, Smit JJ, Hosseini H, De Kimpe SJ, et al. Toll-like receptor 4 mediates cigarette smoke-induced cytokine production by human macrophages. Resp Res 2006; 7: 66.

  35. Michel O, Kips J, Duchateua J, Vertongue F, Robert L, Collet H, et al. Severity of asthma is related to endotoxin in house dust. Am J Respir Crit Care Med 1996; 154: 1641-6.

  36. Eisenbarth SC, Piggott DA, Huleatt JW, Visitin I, Herrick CA, Bottomly K. Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper Cell type 2 responses to inhaled antigen. J Exp Med 2002; 196: 1645-51.

  37. Nigo YI, Yamashita M, Hirahara K, Shinnakasu R, Inami M, Kimura M, et al. Regulation of allergic airway inflammation through toll-like receptor 4-mediated modification of mast cell function. Proc Natl Acad Sci 2006; 103: 2286-91.

  38. Talreja J, Kabir MH, Filla MB, Stechschulte DJ, Dileepan KN. Histamine induces toll-like receptor 2 and 4 expression in endothelial cells and enhances sensitivity to gram-positive and gram-negative bacterial cell wall components. Immunology 2004; 113: 224-33.

  39. Basu S, Fenton MJ. Toll-like receptors: function and roles in lung disease. Am J Physiol Lung Cell Mol Physiol 2004; 286: 887-92.

  40. Jeyaseelan S, Young SK, Yamamoto M, Arndt PG, Akira S, Kolls JK, Worthen GS. Toll/IL1R domain-containing adaptor protein (TIRAP) is a critical mediator of antibacterial defense in the lung against Klebsiella pneumoniae but not Pseudomonas aeruginosa. J Immunol 2006; 177: 538-47.

  41. Srivastava A, Henneke P, Visitin A, Morse SC, Martin V, Watkins C, et al. The apoptotic response to pneumolysin is toll-like receptor 4 dependent and protects against pneumococcal disease. Infect Immun 2005; 73: 6479-87.

  42. Gersuk GM, Underhill DM, Zhu L, Marr KA. Dectin-1 and TLRs permit macrophages to distinguish between different Aspergillus fumigatus cellular states. J Immunol 2006; 176: 3717-24.

  43. Archer KA, Roy CR. MyD88-dependent responses involving toll-like receptor 2 are important for protection and clearance of Legionella pneumophila in a mouse model of legionnaires’s disease. Infect Immun 2006; 74: 3325-33.

  44. Le Goffic R, Balloy V, Lagranderie M, Alexopoulou L, Escriou N, Flavell R, et al. Detrimental contribution of the tolllike receptor (TLR)3 to influenza A virus-induced acute pneumonia. PloS Pathogens 2006; 2: 53.

  45. Adamo R, Sokol S, Soong G, Gomez MI, Prince A. Pseudomonas aeruginosa flagella activate airway epithelial cells through asialoGM1 and toll-like receptor 2 as well as toll-like receptor 5. Am J Respir Cell Mol Biol 2005; 30: 627-34.

  46. Powers MR, Peng Y, Maydanski E, Marshall JS, Lin TJ. The development of early host response to Pseudomonas aeruginosa lung infection is critically dependent on myeloid differentiation factor 88 in mice. J Biol Chem 2004; 279: 49315-22.

  47. Togbe D, Schnyder-Candrian S, Schnyder B, Couillin I, Maillet I, Bihl F, et al. TLR4 gene dosage contributes to endotoxin-induced acute respiratory inflammation. J Leucok Biol 2006; 80: 451-7.

  48. Opal S, Huber CE. Bench to bedside review: Toll-like receptors and their role in septic shock. Critical Care 2002; 6: 125-36.

  49. Delgado MA, Poschet JF, Deretic V. Nonclassical pathway of Pseudomonas aeruginosa DNA- induced interleukin 8 secretion in cystic fibrosis airway epithelial cells. Infect Immun 2006; 74: 2975-84.

  50. Dalpke A, Frank J, Peter M, Heeg K. Activation of toll-like receptor 9 by DNA from different bacterial species. Infect Immun 2006; 72: 940-6.

  51. Rivas-Santiago B, Vieyra-Reyes P, Araujo Z. Cell immunity response in human pulmonary tuberculosis. Invest Clin 2005; 46: 391-412.

  52. Underhill DM, Ozinsky A, Smith KD, Aderem A. Toll-like receptor 2 mediates mycobacteria-induced proinflammatory signaling in macrophages. Proc Natl Acad Sci 1997; 96: 14459-63.

  53. Uehori J, Matsumoto M, Tsuji S. Simultaneous blocking of human toll-like receptors 2 and 4 supresses myeloid dendritic cell activation induced by Mycobacterium bovis Bacillus Calmette- Guérin peptidoglycan. Infect Immun 2003; 71: 4238-49.

  54. Rivas-Santiago B, Schwander SK, Sarabia C, Diamond G, Klein-Patel ME, Hernandez-Pando R, et al. Human β-defensin 2 is expressed and associated with Mycobacterium tuberculosis during infection of human alveolar epithelial cells. Infect Immun 2005; 73(8): 4505-11.

  55. Rivas-Santiago B, Sada E, Tsutsumi V, Aguilar-Leon D, Contreras JL, Hernandez-Pando R. b-Defensin gene expression during the course of experimental tuberculosis infection. J Infect Dis 2006; 194(5): 697-701.

  56. Jung SB, Yang CS, Lee JS, Shin AR, Jung SS, Son JW, et al. The mycobacterial 38-kilodalton glycolipoprotein antigen activates the mitogen-activated protein kinase pathway and release of proinflammatory cytokines through toll-like receptors 2 and 4 in human monocytes. Infect Immun 2006; 74: 2686-96.

  57. Branger J, Leemans JC, Florquin S, Weijer S, Speelman P, van der Poll T. Toll-like receptor 4 plays a protective role in pulmonary tuberculosis in mice. Intr Immunol 2004; 16: 509-16.

  58. Means TK, Jones BW, Schromm AB, Shurtleff BA, Smith JA, Keane J, et al. Differential effects of a toll-like receptor antagonist on Mycobacterium tuberculosis-induced macrophage responses. J Immunol 2001; 166: 4074-82.

  59. Abel B, Thieblemont N, Quesniaux VJF, Brown N, Mpagi J, Miyake K, et al. Toll-like receptor 4 expression is required to control chronic Mycobacterium tuberculosis infection in mice. J Immunol 2002; 169: 3155-62.

  60. Quesniaux VJ, Nicolle DM, Torres D, Kremer L, Guérardel Y, Nigou J, et al. Toll-like receptor 2 (TLR)-dependent-positive and TLR2-independent- negative regulation of proinflammatory cytokines by mycobacterial lipomannans. J Immunol 2004; 172: 4425-34.

  61. Bulut Y, Faure E, Thomas L. Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of toll interacting protein and IL1 receptor signaling molecules in toll-like receptor 2 signaling. J Immunol 2001; 167: 987-94.

  62. Means TK, Wang S, Lien E, Golenbock DT, Fenton M. Human Toll-like receptors mediate cellular activation by Mycobacterium tuberculosis. J Immunol 1999; 163: 3920-7.

  63. Bafica A, Scanga CA, Feng CG, Leifer C, Cheever A, Sher A. TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis. J Exp Med 2005; 202: 1715-24.

  64. Fremond CM, Yeremeev V, Nicolle DM, Jacobs M, Quesniaux VF, Ryffel B. Fatal Mycobacterium tuberculosis infection despite adaptive immune response in the absence of MyD88. J Clin Invest 2004; 114: 1790-9.

  65. Chang JS, Huggett JF, Dheda K, Kim LU, Zumla A, Rook GAW. Mycobacterium tuberculosis induces selective up-regulation of TLRs in the mononuclear leukocytes of patients with active pulmonary tuberculosis. J Immunol 2006; 176: 3010-8.

  66. Arbour NC, Lorenz E, Schutte BC, Zaber J, Kline JN, Jones M, et al. TLR mutations are associated with endotoxin hyporesponsiveness in humans. Nat Gen 2000; 25: 187-91.

  67. Scwartz DA. Inhaled endotoxin, a risk for airway disease in some people. Resp Physiol 2001; 128: 47-55.

  68. Hessel EM, Chu M, Lizcano JO, Chang B, Herman N, Kell SA, et al. Immunostimulaory oligonucleotides block allergic airway inflammation by inhibiting Th2 cell activation and IgE-mediated cytokine induction. J Exp Med 2005; 202: 1563-73.

  69. Galdiero M, Galdiero M, Finamore E, Rossano F, Gambuzza M, Catania RM, et al. Haenophilus influenzae porin induces toll-like receptor 2- mediated cytokine production in human monocytes and mouse macrophages. Infect Immun 2004; 72: 1204-9.




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