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Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

2007, Número 6

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Rev Invest Clin 2007; 59 (6)


Los receptores tipo Toll en la respuesta pulmonar a patógenos

Rivas-Santiago B, Juárez E

Idioma: Español
Referencias bibliográficas: 69
Paginas: 481-488
Archivo PDF: 108.63 Kb.


RESUMEN

La inmunidad innata cumple una función central en la defensa antimicrobiana. Los avances en el conocimiento de los sistemas mediante los cuales las células de la respuesta innata realizan el reconocimiento de los patógenos han permitido identificar, como parte de los mecanismos de defensa de un órgano tan expuesto a una variedad de estímulos como el pulmón, a los receptores tipo Toll (TLR). La respuesta de los TLR al reconocimiento de distintos componentes microbianos induce la producción de citocinas proinflamatorias que pueden tener una función protectora o en detrimento del hospedero. La diversidad de la respuesta inmune humana podría explicar las diferencias en la respuesta que algunos pacientes muestran a las infecciones bacterianas, virales y fúngicas en el pulmón. El diseño de nuevas estrategias para modificar la respuesta inmune innata podría ser muy útil para limitar las consecuencias adversas de los procesos pulmonares inflamatorios.


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