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Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

2007, Number 4

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Rev Invest Clin 2007; 59 (4)

Frequency of high-grade prostatic intraepithelial neoplasia in Mexican population

Arista-Nasr J, Gómez-Ramírez AM, Gonzáles-Romo MA, Maldonado-Martínez HA, Martínez-Benítez B, Lara C, Saqui-Salces M

Language: English
References: 30
Page: 234-238
PDF size: 88.74 Kb.


ABSTRACT

Background. High-grade intraepithelial neoplasia (HGPIN) is the only lesion regarded as precursor of prostatic carcinoma, though its frequency is unknown in many countries. Here we studied the frequency of HGPIN in a population with high grade frequency of prostatic carcinoma. Material and methods. A total of 486 cases of sextant prostatic biopsies performed from January 2001 to January 2006 were reviewed. These included 280 biopsies from patients belonging to an urban population, with medium or high socioeconomic status, from two hospitals in Mexico City. For comparison, 206 cases from the Regional Hospital of Tabasco located in the tropical zone of the country were included. This hospital receives patients from a rural population with low income and socioeconomic status. Results. Of the total 486 cases, 162 (33.33%) cases were diagnosed as prostatic carcinoma and 319 (65.64%) as benign conditions. Only in five (1.03%) biopsies was HGPIN found. Three of these patients were from Mexico City, and two from the Regional Hospital of Tabasco. Conclusions. Even when our results were obtained only in three hospitals, they suggest that a low frequency of HGPIN on needle prostate biopsies does not necessarily mean a low frequency of prostatic carcinoma in the same population. The reason for such a disparity could be related to a reduced extension of HGPIN areas in the prostate gland. In populations with low frequency of HGPIN and high incidence of prostatic carcinoma, perhaps more biopsy cores should be obtained in order to minimize false negative results for premalignant lesions or early adenocarcinoma.


REFERENCES

  1. Bostwick DG, Quian J. High-grade prostatic intraepithelial neoplasia. Mod Pathol 2004; 17: 360-79.

  2. Bostwick DG. Prostatic intraepithelial neoplasia is a risk factor for cancer. Semin Urol Oncol 1999; 17: 187-98.

  3. Jonathan IE, Ximing JY. Prostate biopsy interpretation, 3rd Ed. Biopsy Interpretation Series. Lippincott Williams & Wilkins. Diagnosis of limited adenocarcinoma of the prostate; 2002, p. 64-92.

  4. Aboseif S, Shinohara K, Weidner N, Narayan P, Carroll PR. The significance of prostatic intra-epithelial neoplasia. Br J Urol 1995; 76: 355-9.

  5. Langer JE, Rovner ES, Coleman BG, Yin D, Arger PH, Malkowicz SB, et al. Strategy for repeat biopsy of patients with prostatic intraepithelial neoplasia detected by prostate needle biopsy. J Urol 1996; 155: 228-31.

  6. Lam JS, Desai M, Mansukhani MM, Benson MC, Goluboff ET. Is Hispanic race an independent risk factor for pathological stage in patients undergoing radical prostatectomy? J Urol 2003; 170: 2288-91.

  7. Mohar A, Frías M, Suchil L, Mora T, De la Garza J. Epidemiología descriptiva de cáncer en el Instituto Nacional de Cancerología de México. Salud Pública Mex 1997; 39: 253-58.

  8. Wills ML, Hamper UM, Partin AW, Epstein JI. Incidence of high-grade prostatic intraepithelial neoplasia in sextant needle biopsy specimens. Urology 1997; 49: 367-73.

  9. Sakr W, Grignon DJ, Haas GP, Heilburn LK, Pontes JE, Crissman JD. Pathology of premalignant lesions and carcinoma of the prostate in African-American men. Semin Urol Oncol 1998; 16: 214-20.

  10. Sakr W, Grignon DJ, Haas GP, Heilburn LK, Pontes JE, Crissman JD. Age and racial distribution of prostatic intraepithelial neoplasia. Eur Urol 1996; 30: 138-44.

  11. Fowler JE Jr, Bigler SA, Lynch C, Wilson SS, Farabaugh PB. Prospective study of correlations between biopsy-detected high grade prostatic intraepithelial neoplasia, serum prostate specific antigen concentration and race. Cancer 2001; 91: 1291-6.

  12. Powell IJ. Prostate cancer in the African American: is this a different disease? Semin Urol Oncol 1998; 16: 221-65.

  13. Carver BS, Bozeman CB, Simoneaux WJ, Venable DD, Kattan MW, Eastham JA. Race is not a predictor of prostate cancer detection on repeat prostate biopsy. J Urol 2004; 172: 1853-5.

  14. Humphrey PA. Prostate Pathology. Hong Kong: ASCP Press; 2003, Chapter 11, p. 184-6.

  15. Sakr WA, Billis A, Ekman P, Wilt T, Bostwick DG. Epidemiology of high-grade prostatic intraepithelial neoplasia. Scand J Urol Nephrol Suppl 2000; 205: 11-8.

  16. Hoedemaeker RF, Kranse R, Rietbergen JB, Kruger AE. Evaluation of prostate needle biopsies in a population based screening study. Cancer 1999; 85: 145-52.

  17. Cheville JC, Reznicek MJ, Bostwick DG. The focus of “atypical glands, suspicious for malignancy” in prostatic needle biopsy specimens: incidence, histologic features, and clinical followup of cases diagnosed in a community practice. Am J Clin Pathol 1997; 108: 633-40.

  18. Weinstein MH, Greenspan DL, Epstein JI. Diagnoses rendered on prostate needle biopsy in community hospital. Prostate 1998; 35: 50-5.

  19. Cook LS, Goldoft M, Schwartz SM, Weiss NS. Incidence of adenocarcinoma of the prostate in Asian inmigrants to the United States. J Urol 1999; 161: 152-5.

  20. Angwafo FF III, Zaher A, Menguer RB, Wonkman A. Highgrade intra-epithelial and prostate cancer in Diombari, Cameroon. Prostate Cancer Prostatic Dis 2003; 6: 34-8.

  21. Desai SB, Borges AM. The prevalence of high-grade prostatic intraepithelial neoplasia in surgical resection specimens: an Indian experience. Cancer 2002; 94: 2350-2.

  22. Shirley SE, Escoffery CT, Sargeant LA, Tulloch T. Clinicopathological features of prostate cancer in Jamaican men: BJU Int 2002; 89: 390-95.

  23. Algaba F. Evolution of isolated high-grade prostate intraepithelial neoplasia in a Mediterranean patient population. Eur Urol 1999; 35: 496-7.

  24. Herranz-Amo F, Álvarez-Fernández E, Diez-Cordero JM, Verdu- Tartajo F, Bielsa-Carrillo A, García-Burgos J, et al. Incidence of high grade prostatic intraepithelial neoplasm in transrectal biopsy of the prostate. Arch Esp Urol 2001; 54: 321-6.

  25. Sánchez CM, Angulo JCM, Donat E, Ruiz A, Olmedilla G. Prevalence of prostatic intraepithelial neoplasia in Spain. Arch Esp Urol 2001; 54: 1103-9.

  26. Stewart CS, Leibobich BC, Weaver AL, Lieber MM. Prostate cancer diagnosis using a saturation needle biopsy technique after previous negative sextant biopsies. J Urol 2001; 166: 86-91.

  27. Billis A. Risk of prostate cancer on re-biopsy following a diagnosis of high-grade prostatic intraepithelial neoplasia (HGPIN) is related to the number of cores sampled. Int Braz J Urol 2005; 35: 171-2.

  28. Rodríguez-Duarte C. Multi-core prostatic biopsy. Arch Esp Urol 2002; 55: 907-14.

  29. Dovey Z, Corbishley CM, Kirby RS. Prostatic intraepithelial neoplasia: a risk factor for prostate cancer. Can J Urol 2005; 12(Suppl. 1): 49-52.

  30. Naya Y, Ayala G, Tamboli P, Babaian RJ. Can the number of cores with high-grade prostate intraepithelial neoplasia predict cancer in men who undergo repeat biopsy? Urology 2004; 63: 503-8.




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