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Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

2007, Number 3

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Rev Invest Clin 2007; 59 (3)

Neurotrophic control in the development and function of two endocrine organs: The ovary and the pancreas

Cabrera-Vásquez S

Language: Spanish
References: 66
Page: 219-228
PDF size: 129.63 Kb.


ABSTRACT

Neurotrophins (NTs) are important for the survival, differentiation and function of sympathetic and sensorial neurons of central and peripheral nervous system. However, similar functions have been described of NTs in non-neural organs. Nerve Growth factor (NGF) participates in the foliculogenesis and ovulation in the ovary, as well as in the islet morphogenesis and insulin secretion of the pancreatic β cell. The NTs act by binding to two distinct classes of transmembranal receptors: p75 and Trks. Both receptor types lead to activation of intracellular signaling cascades that end with cell survival or apoptosis. In this review different actions of the NTs in the ovarian and the pancreas are described.


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