medigraphic.com
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

2007, Número 3

<< Anterior

Rev Invest Clin 2007; 59 (3)


El control neurotrófico en el desarrollo y la función de dos órganos endocrinos: el ovario y el páncreas

Cabrera-Vásquez S

Idioma: Español
Referencias bibliográficas: 66
Paginas: 219-228
Archivo PDF: 129.63 Kb.


RESUMEN

Las neurotrofinas (NTs) son indispensables para la sobrevivencia, la diferenciación y la función de neuronas simpáticas y sensoriales del sistema nervioso central y periférico. Sin embargo, se han descrito funciones similares de las NTs en órganos no neuronales. El factor de crecimiento neuronal (NGF) participa en la foliculogénesis y la ovulación en el ovario, así como en la morfogénesis del islote y en la secreción de insulina por la célula β pancreática. Las NTs median sus funciones al unirse a dos diferentes tipos de receptores transmembranales: los Trks y el p75. Ambos tipos de receptores inducen la activación de cascadas de señalización que finalizan con sobrevivencia celular o apoptosis. En esta revisión se describen diferentes acciones de las NTs en el ovario y el páncreas.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Bibel M, Barde YA. Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system. Genes and Development 2000; 14: 2919-37. Review.

  2. Aloe L, Levi MR. The discovery of nerve growth factor and modern neurobiology. Trends Cell Biol 2004; 14(7): 395-9.

  3. Reichardt LF. Neurotrophin-regulated signalling pathways. Philos Trans R Soc Lond B Biol Sci 2006; 361(1473): 1545- 64. Review.

  4. Dissen GA, Romero C, Paredes A, Ojeda SR. Neurotrophic control of ovarian development. Microscopy Reserch and Technique 2002; 59: 509-15. Review.

  5. Muller D, Davidoff MS, Bargheer O, Paust HJ, Pusch W, Koeva Y, et al. The expression of neurotrophins and their receptors in the prenatal and adult human testis: evidence for functions in Leydig cells. Histochem Cell Biol 2006; 126(2): 199-211.

  6. Kanaka GC, Dicou E, Czernichow P, Scharfmann R. Presence of nerve growth factor and its receptors in an in vitro model of islet cell development: Implication in normal islet morphogenesis. Endocrinology 1995; 136(7): 3154-62.

  7. Rosenbaum T, Vidaltamayo R, Sánchez SMC, Zentella A, Hiriart M. Pancreatic β cells synthesize and secrete nerve growth factor. Proc Natl Acad Sci USA 1998; 95: 7784-88.

  8. Lu Bai, Pang PT, Woo NH. The yin and yang of neurotrophin action. Nature Reviews Neuroscience 2005; 6: 603-14.

  9. Kalb R. The protean actions of neurotrophins and their receptors on the life and death of neurons. Trends Neurosci 2005; 28(1): 5-11. Review.

  10. Patapoutian A, Reichardt LF. Trk receptors: mediators of neurotrophin action. Current Opinion in Neurobiology 2001; 11: 272-80. Review.

  11. Chao MV. Neurotrophins and their receptors: a convergence point for many signaling pathways. Nature reviews Neuroscience 2003; 4: 299-309.

  12. Yamashita T, Fujitani M, Hata K, Mimura F, Yamagishi S. Diverse functions of the p75 neurotrophin receptor. Anat Sci Int 2005; 80(1): 37-41. Review.

  13. Hempstead BL. The many faces of p75NTR. Curr Opin Neurobiol 2002; 12(3): 260-7. Review.

  14. Lee R, Kermani P, Teng KK, Hempstead BL. Regulation of cell survival by secreted proneurotrophins. Science 2001; 294(5548): 1945-8.

  15. Kaplan DR, Miller FD. Neurotrophin signal transduction in the nervous system. Current Opinion in Neurobiology 2000; 10: 381-91. Review.

  16. Arevalo JC, Pereira DB, Yano H, Teng KK, Chao MV. Identification of a switch in neurotrophin signaling by selective tyrosine phosphorylation. The Journal of biological chemistry 2006; 281(2): 1001-07.

  17. Mamidipudi V, Wooten MW. Dual role for p75 (NTR) signaling in survival and cell death: can intracellular mediators provide an explanation? J Neurosci Res 2002; 15; 68(4): 373-84. Review.

  18. Maggiwar SB, Sarmiere PD, Dewhurst S, Freeman RS. Nerve growth factor-dependent activation of NFkB contributes to survival of sympathetic neurons. J Neurosci 1998; 18: 10356-65.

  19. Hamanoue M, Middleton G, Wyatt S, Jaffray E, Hay RT, Davies AM. p75-mediated NFkB activation enhance the survival response of developing sensory neurons to nerve growth factor. Mol Cell Neurosci 1999; 14: 28-40.

  20. Muller G, Storz P, Bourtelle S, Doppler H, Pfizenmaier K, Mischak H, et al. Regulation of Raf-1 kinase by TNF via its second messenger ceramide and crosstalk with mitogenic signalling. EMBO J 1998; 17: 732-42.

  21. Zundel W, Swiersz LM, Giaccia A. Caveolin 1-mediated regulation of receptor tyrosine kinase-associated phosphatidylinositol 3-kinase activity by ceramide. Mol Cell Biol 2000; 20: 1507-14.

  22. Bilderback TR, Gazula VR, Dobrowsky RT. Phosphoinositide 3-kinase regulates crosstalk between Trk A tyrosine kinase and p75 (NTR)-dependent sphingolipid signaling pathways. J Neurochem 2001; 76(5): 1540-51.

  23. Dissen GA, Newman Hirshfield A, Malamed S, Ojeda SR. Expression of neurotrophins and their receptors in the mammalian ovary is developmentally regulated: changes at the time of folliculogenesis. Endocrinology 1995; 136: 4681-92.

  24. Spears N, Molinek MD, Robinson LL, Fulton N, Cameron H, Shimoda K, et al. The role of neurotrophin receptors in female germ-cell survival in mouse and human. Development 2003; 130: 5481-91.

  25. Anderson RA, Robinson LL, Brooks J, Spears N. Neurotropins and their receptors are expressed in the human fetal ovary. The Journal of Clinical Endocrinology and Metabolism 2002; 87(2): 890-7.

  26. Dissen GA, Romero C, Newman HA, Ojeda SR. Nerve growth factor is required for early follicular development in the mammalian ovary. Endocrinology 2001; 142: 2078-86.

  27. Hirshfield AN. Development of follicles in the mammalian ovary. Int Rev Citol 1991; 124: 43-101. Review.

  28. Mayerhofer A, Dissen GA, Costa ME, Ojeda SR. A role for neurotransmitters in early follicular development: Induction of functional follicle-stimulating hormone receptors in newly formed follicles of the rat ovary. Endocrinology 1997; 138: 3320-9.

  29. Romero C, Paredes A, Dissen GA, Ojeda SR. Nerve growth factor induces the expression of functional FSH receptors in newly formed follicles of the rat ovary. Endocrinology 2002; 143: 1485-94.

  30. Salas C, Pieper MJ, Valladares M, Pommer R, Vega M, Mastronardi C, et al. Nerve growth factor-dependent activation of trkA receptors in the human ovary results in synthesis of follicle- stimulating hormone receptors and estrogen secretion. J Clin Endocrinol Metab 2006; 91(6): 2396-403.

  31. Ojeda SR, Romero C, Tapia V, Dissen GA. Neurotrophic and cell-cell dependent control of early follicular development. Mol Cell Endocrinol 2000; 163(1-2): 67-71.

  32. Paredes A, Romero C, Dissen GA, DeChiara TM, Reichardt L, Cornea A, et al. TrkB receptors are required for follicular growth and oocyte survival in the mammalian ovary. Developmental Biology 2004; 267: 430-49.

  33. Brannstrom M, Enskog A. Leukocyte networks and ovulation. J Reprod Immunol 2002; 57(1-2): 47-60. Review.

  34. Richards JS. Ovulation: new factors that prepare the oocyte for fertilization. Mol Cell Endocrinol 2005; 234(1-2): 75-9. Review.

  35. Dissen GA, Hill DF, Costa ME, Dees WL, Lara HE, Ojeda SR. A role for TrkA nerve growth factor receptor in mammalian ovulation. Endocrinology 1996; 137: 198-209.

  36. Hurwitz A, Ricciarelli E, Botero L, Rohan RM, Hernandez ER, Adashi EY. Endocrine -and autocrine- mediaded regulation of rat ovarian (teca-interstitial) interleukin-1β gene expression: Gonadotropin-dependent preovulatory acquisition. Endocrinology 1991; 129: 3427-9.

  37. Dissen GA, Parrott JA, Skinner MK, Hill DF, Costa ME, Ojeda SR. Direct effects of nerve growth factor on thecal cells from antral ovarian follicles. Endocrinology 2000; 141: 4736-50.

  38. Mayerhofer A, Dissen GA, Parrott JA, Hill DF, Mayerhofer D, Garfield RE, et al. Involvement of nerve growth factor in the ovulatory cascade: TrkA receptor activation inhibits gap junctional communication between thecal cells. Endocrinology 1996; 137(12): 5662-70.

  39. Kanaka GC, Tazi A, Czernichow P, Scharfmann R. In vivo presence of the high affinity nerve growth factor receptor Trk- A in the rat pancreas: Diferential localization during pancreatic development. Endocrinology 1995; 136(2): 761-9.

  40. Edwards RH, Rutter WJ, Hanahan D. Directed expression of NGF to pancreatic beta cells in transgenic mice leads to selective hyperinnervation of the islet. Cell 1989; 58(1): 161-70.

  41. Reimer MK, Mokshagundam SP, Wyler K, Sundler, Ahren B, Stagner JI. Local growth factors are beneficial for the autonomic reinnervation of transplantes islet in rats. Pancreas 2003; 26(4): 392-7.

  42. Vidaltamayo R, Mery CM, Ángeles AA, Robles DG, Hiriart M. Expression of nerve growth factor in human pancreatic β cells. Growth Factors 2003; 21(3-4): 103-7.

  43. Vidaltamayo R, Sánchez SMV, Rosenbaum T, Martínez MT, Hiriart M. Neuron-like phenotypic changes in pancreatic β-cells induced by NGF, FGF, and dbcAMP. Endocrine 1996; 4(1): 19-26.

  44. Rosenbaum T, Vidaltamayo R, Sánchez HD, Hiriart M. Nerve growth factor increases sodium current in pancreatic β cell. J Membr Biol 1996; 153: 53-8.

  45. Rosenbaum T, Castanares DT, López VHE, Hiriart M. Nerve growth factor increases L-type calcium current in pancreatic beta cells in culture. J Membr Biol 2002; 186(3): 177-84.

  46. Rosenbaum T, Sánchez SMC, Hiriart M. Nerve growth factor increases insulin secretion and barium current in pancreatic β- cells. Diabetes 2001; 50: 1755-62.

  47. Navarro TV, Sánchez SMC, García S, Hiriart M. Autocrine regulation of single pancreatic beta-cell survival. Diabetes 2004; 53(8): 2018-23.

  48. Miao G, Mace J, Kirby M, Hopper A, Peverini R, Chinnock R, et al. Beneficial effects of nerve growth factor on islet transplantation. Transplant Proc 2005; 37(8): 3490-2.

  49. Larrieta ME, Vital P, Mendoza RA, Cerbon M, Hiriart M. Nerve growth factor increases in pancreatic β cells after streptozotocin- induced damage in rats. Exp Biol Med 2006; 231(4): 396-402.

  50. Lucini C, Maruccio L, De Girolamo P, Castaldo L. Brain-derived neurotrophic factor in higher vertebrate pancreas: inmunolocalization in glucagon cells. Anatomy and Embriology 2003; 4: 311-8.

  51. Hanyu O, Yamatani K, Ikarashi T, Soda S, Maruyama S, Kamimura T, et al. Brain-derived neurotrophic factor modulates glucagon secretion from pancreatic alpha cells: its contribution to glucose metabolism. Diabetes, Obesity and Metabolism 2003; 5: 27-37.

  52. Shibayama E, Koizumi H. Cellular localization of the Trk neurotrophin receptor family in human non-neuronal tissues. Am J Pathol 1996; 148(6): 1807-18.

  53. Ono M, Ichihuara J, Nonomura T, Itakura Y, Taiji M, Nakayama C, Noguchi H. Brain derived neurotrophic factor reduces blood glucose level in obese diabetic mice but not in normal mice. Biochem Biophys Res Commun 1997; 18: 633-7.

  54. Yamanaka M, Itakura Y, Inoue T, Tsuchida A, Nakagawa T, Noguchi H, Taiji M. Protective effect of brain-derived neurotrophic factor on pancreatic islets in obese diabetic mice. Metabolism 2006; 55(10):1286-92.

  55. Seifer DB, Feng Bo, Shelden RM. Immunocytochemical evidence for the presence and location of the neurotrophin-Trk receptor family in adult human preovulatory ovarian follicles. American Journal of Obstetrics and Gynecology 2006; 194: 1129-36.

  56. Pieper MJ, Lara HE, Bravo JA, Romero C. Effects of nerve growth factor (NGF) on blood vassels area and expresion of the angiogenic factors VEGF and TGFbeta in the rat ovary. Reproductive Biology and Endocrinology 2006; 4(57). Published on line.

  57. Nockher WA, Renz H. Neurotrophins in allergic diseases: from neuronal growth factors to intercellular signaling molecules. J Allergy Clin Immunol 2006; 117(3): 583-9. Review.

  58. Rochlitzer S, Nassenstein C, Braun A. The contribution of neurotrophins to the pathogenesis of allergic asthma. Biochem Soc Trans 2006; 34: 594-9. Review.

  59. Kobayashi H, Gleich GJ, Butterfield JH, Kita H. Human eosinophils produce neurotrophins and secrete nerve growth factor on immunologic stimuli. Blood 2002; 99(6): 2214-20.

  60. Aalto K, Korhonen L, Lahdenne P, Pelkonen P, Lindholm D. Nerve growth factor in serum of children with systemic lupus erythematosus is correlated with disease activity. Cytokine 2002; 20(3): 136-9.

  61. Faradji V, Sotelo J. Low serum levels of nerve growth factor in diabetic neuropathy. Acta Neurol Scand 1990; 81(5): 402-6.

  62. Hwang JP, Tsai SJ, Hong CJ, Yang CH, Lirng JF, Yang YM. The Val66Met polymorphism of the brain-derived neurotrophic- factor gene is associated with geriatric depression. Neurobiol Aging 2006; 27(12): 1834-7.

  63. Sklar P, Gabriel SB, McInnis MG, Bennett P, Lim YM, Tsan G, et al. Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain- derived neutrophic factor. Mol Psychiatry 2002; 7(6): 579-93.

  64. Neves PM, Cheung JK, Pasdar A, Zhang F, Breen G, Yates P, et al. BDNF gene is a risk factor for schizophrenia in a Scottish population. Mol Psychiatry 2005; 10(2): 208-12.

  65. Tuszynski MH, Thal L, Pay M, Salmon DP, U HS, Bakay R, et al. A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease. Nat Med 2005; 11(5): 551-5.

  66. Kruttgen A, Schneider I, Weis J. The dark side of the NGF family: neurotrophins in neoplasias. Brain Pathol 2006; 16(4): 304-10.




2020     |     www.medigraphic.com