2013, Number 1
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An Med Asoc Med Hosp ABC 2013; 58 (1)
Comparative study of the efficiency of tetracaine versuslidocaine intraurethral for the accomplishment of rigid cystoscopy in men
Lomelín-Ramos JP, Almanza-González MS, Maldonado-Ávila M, Rosas-Nava JE, Cumming-Martínez BA
Language: Spanish
References: 25
Page: 5-9
PDF size: 63.99 Kb.
ABSTRACT
Background: Cystoscopy constitutes a very helpful tool for diagnostic and treatment of multiple urologic diseases. In these days there is controversy in literature about the efficacy of local intraurethral anaesthetics for performing cystoscopy.
Objective: To compare the effectiveness between intraurethral tetracaine and lidocaine for performing cystoscopy in men.
Material and methods: Prospective, comparative, simple blind, randomized, clinical assay. A total of 60 patients were included in the study, randomly divided into 3 groups of 20 each. It was applied 0.5%, lidocaine 2% and placebo via intrauretral, according to groups, the patient was asked to determine the intensity of pain during the procedure according to visual analogue pain scale.
Results: We found statistical significant difference between the tetracaine (p ‹ 0.001) and lidocaine (p = 0.003) versus placebo. No statistical significant difference was found between lidocaine and tetracaine (p = 0.377).
Conclusion: It was found statistically significant decrease in pain caused by performing cystoscopy in men who received intraurethral tetracaine and lidocaine 5 minutes before the procedure, compared to placebo.
REFERENCES
Potenziani J. Historia de la Urología (I). Del mundo antiguo al siglo XX. VITAE Academia Biomédica Digital [revista en internet] 2006; 26 [Accesado el 20 abril de 2010]. Disponible en: http://vitae.ucv.ve/?module=articulo&rv=6&n=196&m=4&e=205
Vinod M et al. Miller’s anesthesia. 7th ed. Elsevier Churchill Livingstone; 2009 [Accesado el 20 abril de 2010]. Available in: http://www.mdconsult.com/das/book/body/2066303798/0/2053/68.html?tocnode=57526965&fromURL=68.html#4-u1.0-B978-0-443-06959-8..00065-0_4082 20 X
Dagnino Sepúlveda J. Respuesta Sistémica al dolor agudo. Boletín de la Escuela de medicina. Universidad Católica de Chile 1994; 23: 152-154.
Goodman & Gilman, eds. Las bases farmacológicas de la terapéutica. 11Ş ed. México. McGraw-Hill-Interamericana; 2008: 369-385.
Harmatz A. Local anesthetics: uses and toxicities. Surg Clin North Am 2009; 89 (3): 587-598.
Patel AR, Jones JS, Babineau D. Lidocaine 2% gel versus plain lubricating gel for pain reduction during flexible cystoscopy: a meta-analysis of prospective, randomized, controlled trials. J Urol 2008; 179 (3): 986-990.
Goldfischer ER, Cromie WJ, Karrison TG, Naszkiewicz L et al. Randomized, prospective, double-blind study of the effects on pain perception of lidocaine jellies versus plain lubricant during outpatient rigid cystoscopy. J Urol 1997; 157 (1): 90-94.
Tzortzis V, Gravas S, Melekos MM, de la Rosette JJ. Intraurethral lubricants: a critical literature review and recommendations. J Endourol 2009; 23 (5): 821-826.
Choong S, Whitfield HN, Meganathan V, Nathan MS, Razack A, Gleeson M. Prospective, randomized, double-blind study comparing lignocaine gel and plain lubricating gel in relieving pain during flexible cystoscopy. Br J Urol 1997; 80 (1): 69-71.
Holmes M, Stewart J, Rice M. Flexible cystoscopy: is the volume and content of the urethral gel critical? J Endourol 2001; 15 (8): 855-858.
McFarlane N, Denstedt J, Ganapathy S, Razvi H. Randomized trial of 10 and 20 mL of 2% intraurethral lidocaine gel and placebo in men undergoing flexible cystoscopy. J Endourol 2001; 15 (5): 541-544.
Palit V, Ashurst HN, Biyani CS, Elmasray Y, Puri R, Shah T. Is using linocaine gel prior to flexible cystoscopy justified? A randomized prospective study. Urol Int 2003; 71 (4): 389-392.
Rodriguez-Rubio F, Sanz G, Garrido S, Sánchez C, Estudillo F. Patient tolerance during outpatient flexible cystoscopy: a prospec
tive, randomized, double-blind study comparing plain lubrication and lidocaine gel. Scand J Urol Nephrol 2004; 38 (6): 477-480.
Chen YT, Hsiao PJ, Wong WY, Wang CC, Yang SS, Hsieh CH. Randomized double-blind comparison of lidocaine gel and plain lubricating gel in relieving pain during flexible cystoscopy. J Endourol 2005; 19 (2): 163-166.
Birch BR, Ratan P, Morley R, Cumming J, Smart CJ, Jenkins JD. Flexible cystoscopy in men: is topical anaesthesia with lignocaine gel worthwhile? Br J Urol 1994; 73 (2): 155-159.
Burke DM, Shackley DC, O’Reilly PH. The community-based morbidity of flexible cystoscopy. BJU Int 2002; 89 (4): 347-349.
Dryhurst DJ, Fowler CGA. New small-calibre diagnostic flexible cystoscope. BJU Int 2002; 89 (3): 194-196.
Goel R, Aron M. Cooled lignocaine gel: does it reduce urethral discomfort during instillation? Int Urol Nephrol 2003; 35 (3): 375-377.
Ho KJ, Thompson TJ, O’Brien A, Young MRA, McCleane G. Lignocaine gel: does it cause urethral pain rather than prevent it? Eur Urol 2003; 43 (2): 194-196.
Jayathillake A, Mason DF, Broome K, Tan G. Chlorhexidine in urethral gel: does it cause pain at flexible cystoscopy. Urology 2006; 67 (4): 670-673.
Khan MA, Beyzade B, Tau W, Virdi JS, Potluri BS. Effect of the rate of delivery of lignocaine gel on patient discomfort perception prior to performing flexible cystoscopy. Urol Int 2002; 68 (3): 164-167.
Hozo SP, Djulbegovic B, Hozo I. Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol 2005; 5 (1): 13.
Bugedo G, Dagnino J, Muńoz H, Torregrosa S. Escala visual análoga: comparación de seis escalas distintas. Rev Chil Anestesia 1989; 18: 132.
Mendoza-Álvarez LA, Pares-Hipólito J, Flores-Terrazas E, Campos-Salcedo JG, Torres-Salazar JJ, López SJ et al. Efectividad de una preparación de lubricante anestésico intrauretral en la disminución del dolor durante la cistoscopia rígida en pacientes masculinos. Rev Mex Urol 2009; 69 (3): 88-93.