2012, Number 12
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MediSan 2012; 16 (12)
Laboratory tests in Gilbert's syndro me subsequent to hepatitis
Robert TV, del Valle DS, Durañones GS, Domínguez CMC, Clares PMC
Language: Spanish
References: 18
Page: 1823-1830
PDF size: 197.37 Kb.
ABSTRACT
A descriptive and cross-sectional study was carried out in 40 patients with Gilbert's
syndrome subsequent to viral hepatitis, admitt
ed to the Internal Medicine Department of
"Saturnino Lora Torres" Provincial Clinical Surgical Teaching Hospital of Santiago de Cuba
or to the specialized hepatology service of the Polyclinic of Specialties in this institution,
from June 2011 to the same month of 2012,
to determine the cl
inical and humoral
characteristics and the response to medica
l treatment in them. Means, medians and
standard deviations were evaluated in the
case material, and among the results was a
greater representation of males younger th
an 36 years (90.0% of the total), and a
prevalence of manifestations of drowsiness,
followed by sleepiness, mild jaundice and
absence of symptoms was observed. Also, the elevation of indirect bilirrubin and its
subsequent reduction when applying therapy
with an enzyme inducer, phenobarbital in
this case, were confirmed, eventually obtaining clinical and humoral improvement of
patients.
REFERENCES
Ganong Willian F. Fisiología médica. 20 ed. México, D.F.: Editorial El Manual Moderno; 2005.
Guyton-HALL. Tratado de fisiología médica. 10 ed. México. McGraw-Hill Interamericana; 2004.
Argente HA, Álvarez ME. Semiología médica: fisiopatología, semiotecnia y propedéutica. Buenos Aires: Editorial Médica Panamericana; 2005.
Goic A, Chamorro G, Reyes H. Semiología médica. 2 ed. Providencia, Santiago de Chile: Editorial Mediterráneo; 1999.
Labrune P. Síndrome de Gilbert [citado 23 Abr 2012]. Disponible en: http://www.orpha.net/consor/cgi-b in/OC_Exp.php?lng=ES&Expert=357
Berk PD, Korenblat KM. Approach to the pati ent with jaundice or abnormal liver test results. En: Goldman L, Ausiello D. Cecil Medicine. 23 ed. Philadelphia, Pa: Saunders Elsevier; 2009.
Villanueva Curto S, Molina Ramos R, Molina Ramos JM. Enfermedad de Gilbert y esquizofrenia. Actas Esp Psiquiatr. 2006; 34(3): 206-8.
Campuzano Maya, German. Síndrome de Gilbert, ¿qué es y cómo diagnosticarlo? Med Lab. 2006; 12(7/8): 311-23.
Gilbert's disease. En: MedlinePlus [citado 23 Abr 2012]. Disponible en: http://www.nlm.nih.gov/medlin eplus/ency/article/000301.htm
Marcuello E, Altés A, Menoyo A, Del Rio E, Gómez-Pardo M, Baiget M. UGT1A1 gene variations and irinotecan treatment in patients with metastatic colorectal cancer. Br J Cancer. 2004; 91(4): 678-82.
Rauchschwalbe S, Zühlsdorf M, Wensing G, Kuhlmann J. Glucuronidation of acetaminophen is independent of UGT1A1 pr omotor genotype. Int J Clin Pharmacol Ther. 2004; 42(2): 73-7.
Köhle C, Möhrle B, Münzel PA, Schwab M, Wernet D, Badary OA, et al. Frequent co- occurrence of the TATA box mutation associated with Gilbert's syndrome (UGT1A1*28) with other polymorphisms of the UDP-glucuronosyltransferase-1 locus (UGT1A6*2 and UGT1A7*3) in Caucasians an d Egyptians. Biochem Pharmacol. 2003; 65(9): 1521-7.
Esteban A, Pérez-Mateo M. Heterogeneity of paracetamol metabolism in Gilbert's syndrome. Eur J Drug Metab Pharmacokinet. 1999; 24(1): 9–13.
Mukherjee S. Gilbert syndrome [citado 28 Abr 2012]. Disponible en: http://www.emedicine.com/med/topic870.htm
Gitlin N. The clinical presentation of Gilbert's disease in 26 patients. S Afr Med J. 1977; 52(1): 19-20.
Olsson R, Bliding A, Jagenburg R, Lapidus L, Larsson B, Svärdsudd K, et al. Gilbert's syndrome--does it exist? A study of the prevalence of symptoms in Gilbert's syndrome. Acta Med Scand. 1988; 224(5): 485-90.
Temple Larissa, McLeod RS, Gallinger S, Wright JG. Defining disease in the genomics Era. Science. 2007; 293(5531): 807-8.
American Academy of Pediatrics. Management of hyperbilirubinemia in the Newborn Infant 35 or More Weeks of Ge station. Pediatrics. 2004; 114(1): 297- 316.