Ramírez-Hernández F, Hernández-Revilla M, Guzmán-Sánchez JA

Language: Spanish
References: 12
Page: 139-143
PDF size: 60.60 Kb.

ABSTRACT

Background: Changes in acid-base balance caused by infusion of a 0.9% saline solution during anesthesia and surgery are poorly characterized. Therefore, the authors evaluated these phenomena in kidney donors. Methods: Twenty-one patients undergoing nephrectomy as part of a protocol for live-donor transplant were studied. These patients received 0.9 % saline solution until the nephrectomy was performed. Blood samples were taken from the radial artery to measure pH, arterial carbon dioxide tension, and serum levels of sodium, potassium, bicarbonate and chloride at three different times during surgery. The anion gap was estimated as [serum sodium] – [serum chloride] – [serum bicarbonate]. Results: Infusion of 0.9% saline solution caused metabolic acidosis with hyperchloremia. Review of the electrolytes revealed a normal anion gap. Conclusions: Infusion of 15 ± 3.7 ml/kg/h saline solution during anesthesia and surgery leads to metabolic acidosis. Acidosis is associated with hyperchloremia.

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