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Órgano Oficial del Instituto de Ciencias de la Salud, Hospital Escuela y Facultad de Medicina-Xalapa

2012, Number S1

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Rev Med UV 2012; 12 (S1)

Programmed Neuronal Necrosis

López-Meraz ML, Juárez-Aguilar E, Medel-Matus JS, Álvarez CDM, Galán ZR, Pérez ECA, Hernández ME, Miquel M, Manzo J

Language: Spanish
References: 36
Page: 17-22
PDF size: 425.13 Kb.


ABSTRACT

Cell death has been classified in different types considering the morphological features displayed; the main categories are necrosis and apoptosis. Necrosis is characterized by rupture of plasmatic membrane and organelle swelling, while apoptosis courses with high chromatin condensation without disruption of cell membrane. Traditionally, apoptosis has been denominated programmed cell death, since it is associated with the execution of an orchestrated program which implies gen expression, protein synthesis and caspase activation; whereas necrosis has been considered a passive and disordered phenomenon generated by the massive influx of ions and water to the cell. However, recent evidence points to the existence of a type of cell death with necrotic morphology, which implies the execution of well-regulated cell events. Specifically for neurons, this type of active necrosis has been observed under specific experimental conditions and has been termed programmed necrosis or necroptosis. The goal of this review is to describe the mechanisms known about these forms of necrosis in neurons emphasizing the knowledge existing nowadays about programmed necrosis.


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