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2012, Number S1

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Rev Med UV 2012; 12 (S1)

Mechanisms of Axonal Projection during Development, Important lessons for Neuroregeneration and Biomaterials Fields

Tamariz DEH

Language: Spanish
References: 132
Page: 6-16
PDF size: 539.84 Kb.


ABSTRACT

During development neural axons navigate to reach their target and to wire the nervous system. Several guidance cues are involved in the correct innervation and in the targeting of the axons. Guidance cues can be up or down regulated in the adult tissue as compared with the embryonic tissue, or can be expressed in different locations than during development. During regeneration of the adult nervous system exists a fine regulation of guidance cues, influencing in a positive or negative way the regeneration process of the damaged tissue. In this review the different kind of guidance cues present during the embryonic development are summarized, focusing on their role of wiring the nervous system; besides, it will be discussed the importance to understand some aspects of the adult neural tissue regeneration, particularly to enhance regeneration through neuronal replacement therapies and to develop materials for medical applications.


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