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2012, Number 4

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Rev cubana med 2012; 51 (4)

Subcutaneous pheohyphomycosis in a renal transplanted patient

Borroto DG, Henríquez ZF, Guerrero DC, Cairo BJ, Arteaga HE

Language: Spanish
References: 15
Page: 336-343
PDF size: 130.56 Kb.


ABSTRACT

Pheohyphomycosis is a rare disease caused by Dematiaceae family hypha-forming fungi; it mainly affects immunosuppresed patients and causes subcutaneous lesions in the form of cysts and pseudocysts that are mostly treated with surgery and amphotericin B and Itraconazol-based treatment. A case of pheohyphomycosis was presented in a 38 years-old man with a history of chronic renal disease and of hepatitis C caught in hemodialysis. He was a renal transplant recipient in 2010 and was administered a triple immunosuppressive treatment with tacrolimus, mycophenolate mophetil and prednisone. He developed post-transplant diabetes mellitus and one year after the transplantation, he presented with purplish blue-colored pseudocystic dermatological lesions forming clusters in his calves, ankles and toes. The clinical, mycological and biopsy exams of the lesions yielded the diagnosis of pheohyphomycosis. The lesions were surgically removed and then 200mg of itraconazol was administered daily. This treatment was changed on account of the interaction between itraconazol and the anti-calcineuric drugs. The patient was then prescribed everolimus. Three months later, the patient recovered satisfactorily.


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