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2005, Number 2

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Rev Endocrinol Nutr 2005; 13 (2)

Cutaneous manifestations of diabetes mellitus, a clinic manner for identify the disease

Miracle LS, Barreda BF

Language: Spanish
References: 21
Page: 75-87
PDF size: 183.45 Kb.


ABSTRACT

The term Diabetes Mellitus encompasses a group of metabolic diseases characterized by hyperglycemia, which is produced by a defect in insulin secretion, a defect in insulin action, or both. The chronic hyperglycemia of diabetes is associated with long-term damage, such as organ dysfunction or failure. The acute manifestations that come from hyperglycemia, hyperlipidemia, symptomatic diabetes and ketoacidosis are treated and corrected with insulin or hypoglycemic drug therapy. Never the less, all forms of diabetes in the long run are associated with multiple degenerative alterations that affect the cardiovascular system, the central nervous system, the eyes and the skin. The effects upon the blood vessels are the cardinal pathological factors. The cutaneous complications associated with this disease are worth been studied by physicians because of their numerous and complicated repercussions. The previous estimations of the clinical manifestations of diabetes mellitus were around 30%. In fact, the actual current prevalence of cutaneous manifestations of diabetes is probably close to 100%, especially if one looks for the metabolic effects in the micro and macro circulation and the changes in collagen in the skin.


REFERENCES

  1. The Expert Committee on the diagnosis and classification of Diabetes Mellitus. Report of the Expert Committee on the diagnosis and classification of Diabetes Mellitus. Diabetes Care 1997; 20: 7.

  2. Pfeiffer MA, Halter JB, Porte D Jr. Insulin Secretion in Diabetes Mellitus. Am J Med 1981; 70: 579-588.

  3. Martin BD, Warram JH, Krolewsky AS et al. Role of glucose and insulin resistance in development of type II diabetes mellitus: Result of a 25 year follow up study. Lancet 1992; 340: 925-929.

  4. Kahn CR. Insulin action, diabetogenes and the cause of type II diabetes. Diabetes 1994; 43: 1066-1084.

  5. Romano G, Di Benedetto A, Cesare E, Russo G, Califano L, Cucinotta D. Skin lesions in Diabetes Mellitus: prevalence and clinical correlations. Diabetes Res Clin Pract 1998; 39: 2101-2106.

  6. Aye M, Masson EA. Dermatological care of the diabetic foot. Am J Clin Dermatol 2002; 3(7): 463-474.

  7. Fitzpatrick. Dermatology for the general practitioner. Ed. McGraw-Hill 1996.

  8. Perez M, Kohn S. Cutaneous manifestations of Diabetes Mellitus. J Am Acad Dermat 1994; 30(5): 519-531.

  9. Huntley A. Cutaneous Manifestations of Diabetes Mellitus. Dermatol Cli 1989; 7: 531-546.

  10. Yosipovitch G, Hodak E, Vardi P, Shraga, Karp M. The prevalence of cutaneous Manifestations in IDMM patients and their association and microvascular complications. Diabetes Care 1998; 21(4): 506-509.

  11. Arenas. Dermatología: Atlas, diagnóstico y tratamiento. Segunda edición, Ed McGraw-Hill 1995.

  12. Kemmerly SA. Dermatological manifestations of infections in diabetics. Infect Dis Clin North Am 1994; 8(3): 523-532.

  13. Sibbald RG, Landolt SJ, Toth D. Skin and Diabetes. Endocrinol Metab Clin North Am 1996; 25(2): 463-472.

  14. Thappa DM. Skin Tags as marker of Diabetes Mellitus: an epidemiological study in India. J Dermatol 1995; 22(10): 729-731.

  15. Forst T, Kann P, Pfutzner A, Lobmann R, Schafer H, Beyer J. Association between “diabetic thick skin syndrome” and neurological disorders in Diabetes Mellitus. Acta Diabetol 1994; 31(2): 73-77.

  16. Tuzun B, Tuzun Y, DinVVag N, Minareci O, Ozturk S. Diabetic sclerodactyly. Diabetes Res Clin Pract 1995; 27(2): 153-157.

  17. Maekawa Y, Nakamura T, Nogami R. Scleroderma-like changes in a patient with insulin-dependent Diabetes Mellitus. J Dermatol 1995; 22(7): 508-511.

  18. Stansberry KB, Hill MA, Shapiro SA, McNitt PM, Bhatt BA. Impairment of peripheral blood flow in Diabetes resembles an enhanced aging effect. Diabetes Care 1997; 20(11): 1711-1716.

  19. Jaap AJ, Shore AC, Stockman AJ, Tooke JE. Skin capillary density in subjects with impaired glucose tolerance and patients with type 2 Diabetes. Diabet Med 1996; 13(2): 160-164.

  20. Shemer A, Bergman R, Linn S, Kantor Y, Friedman R. Diabetic dermopathy and internal complications in Diabetes Mellitus. Int J Dermatol 1998; 37(2): 113-115.

  21. Requena L, Sarasa JL, Pique E, Farina MC, Olivares M, Martin L. Clear-cell porocarcinoma: another cutaneous marker of Diabetes Mellitus. Am J Dermatopathol 1997; 19(5): 540-544.




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