Rivera MP

Language: Spanish
References: 17
Page: 17-21
PDF size: 309.05 Kb.

ABSTRACT

We performed a comparative pilot study to assess the effectiveness of platelet-rich plasma in the treatment of chronic ulcers (venous pressure or metabolic). Group I consisted of 11 patients treated with meshed grafts and covered with rich plasma platelet, and group II consisted of seven patients treated only with meshed grafts. We determined integration of the graft, fibroplasia, epithelialization and angiogenesis. In the group treated with platelet rich plasma, a better graft integration was found, and more epithelialization, fibroplasia and angiogenesis. In this study we observed that the use of platelet rich plasma in the management of chronic ulcers, promotes regeneration of tissues and therefore, the recovery of the damaged areas.

REFERENCES

1. Jones KR, Finnie K, Lenihan A. Chronic wounds: factors influencing healing within 3 months and no healing after 5-6 months of care. Wounds 2007; 19(3): 51-63.

2. Singer AJ, Clark, RA. Mechanisms of disease: cutaneous wound healing. N Engl J Med 1999; 341(10): 738-746.

3. Arredondo A, Zúñiga A. Economic consequences of epidemiological changes in diabetes in middle-income countries. Diabetes Care 2004; 27: 104-109.

4. Rathur HM, Boulton AJ. The neuropathic diabetic foot. Nature Clinical Practice Endocrinology & Metabolism 2007; 3(1): 14-25.

5. Brem H, Tomic-Canic M. Cellular and molecular basis of wound healing in diabetes. J Clin Invest 2007; 117(5): 1219-1222.

6. Barron GS, Jacob SE, Kirsner RS. Dermatologic complications of chronic venous disease: medical management and beyond. Ann Vasc Surg 2007; 21(5): 652-62.

7. Menke NB, Ward KR, Witten TM, Bonchev DG, Diegelmann RF. Impaired wound healing. Clin Dermatol 2007; 25(1): 19-25.

8. Brem H, Tomic-Canic M, Tarnovskaya A, Ehrlich HP, Baskin-Bey E et al. Healing of elderly patients with diabetic foot ulcers, venous stasis ulcers, and pressure ulcers. Surg Technol Int 2003; 11: 161-167.

9. McIsaac C. Managing wound care outcomes. Ostomy Wound Manage 2005; 51(4): 54-56.

10. Mazzucco L, Médici D, Serra M, Panizza R, Rivara G et al. The use of autologous platelet gel to treat difficult-to-heal wounds: a pilot study. Transfusion 2004; 44: 1013-1018.

11. Eppley BL, Woodell JE, Higgins J. Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing. Plast Reconstr Surg 2004; 114(6): 1502-1508.

12. Steenvoorde P, van Doorn LP, Naves C, Oskam J. Use of autologous platelet-rich fibrin on hard-to-heal wounds J Wound Care 2008; 17(2): 60-63.

13. Roukis TS, Zgonis T, Tiernan B. Autologous platelet-rich plasma for wound and osseous healing: a review of the literature and commercially available products. Adv Ther 2006; 23(2): 218-237.

14. Brem H, Jacobs T, Vileikyte L, Weinberger S, Gibber M, Gill K et al. Wound-healing protocols for diabetic foot and pressure ulcers. Surg Technol Int 2003; 11: 85-92.

15. Halme DG, Kessler DA. FDA regulation of stem-cell–based therapies. N Engl J Med 2006; 355 (19); 1730-1735.

16. Kessler DA, Siegel JP, Noguchi PD, Zoon KC, Feiden KL, Woodcock J. Regulation of somatic-cell therapy and gene therapy by the food and drug administration. N Engl J Med 1993; 329(16): 1169-1173.

17. Everts PA, Knape JT, Weibrich G, Schönberger JPAM, Hoffmann JJHL, Overdevest EP et al. Platelet rich plasma and platelet gel, a review. J Extra Corpor Techn 2006; 38: 174-187.