Martínez MJR, Ortiz LJB

Idioma: Español
Referencias bibliográficas: 65
Paginas: 22-32
Archivo PDF: 498.10 Kb.

RESUMEN

La cicatriz queloide es una lesión patológica caracterizada por proliferación excesiva de colágena en la dermis papilar que sobrepasa los bordes originales de la herida. Se estudiaron 20 casos de cicatriz queloide (60% mujeres [n = 12] y 40% hombres [n = 8]) con una media de edad de 33 años con seguimiento durante un año (mayo 2010-mayo 2011). Se describieron las lesiones mediante los parámetros de la escala de Vancouver. Se realizó resección quirúrgica y una selección aleatoria simple en dos grupos, Grupo A: de imiquimod crema 5% cada 24 h por ocho semanas y Grupo B: de triamcinolona 10-40 mg/mL cada mes (cuatro aplicaciones). Los pacientes fueron revisados a los siete días, dos semanas y cuatro semanas durante el primer mes, y luego de manera mensual durante el primer semestre y al año del procedimiento. Se evidenció mejoría global en el aspecto y características de la cicatriz con significancia estadística (t = 8.320, gl = 19, p ‹ 0.05). De manera comparativa en ambos grupos también pudo documentarse diferencia estadística a favor del imiquimod (F = 8.337, gl = 9, p ‹ 0.05) comparado con triamcinolona (F = 4.743, gl = 9, p ‹ 0.05); además, ambos grupos lograron una tendencia favorable en cuanto a las características de la cicatriz y el descenso de la escala de Vancouver.

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