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Patología Revista Latinoamericana

2012, Number 4

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Patol Rev Latinoam 2012; 50 (4)

Ten years of p16 in biopsy of cervix, worth its routine use?

Curiel VJJ

Language: Spanish
References: 24
Page: 293-304
PDF size: 637.69 Kb.


ABSTRACT

In the cervical uterine cancer diagnosis chain, the biopsy is categorical, and is a fact that HPV is involved in this event but not the only cause, it creates dysplasia and only in a few of the initially infected cases, cancer. The microscopic appearance of the transformation zone of the cervix is complex and specially when infected by HPV, these microscopic images are frequently misdiagnosed as CIN and in a few cases as metaplasia. Some molecular markers to clear this issue where developed and p16 is the most highlighted of them, and despite that is very useful especially in high-grade lesions it is no used routinely. This review deals with the experience of almost 10 year with this marker in uterine cervix.


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