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2012, Number 4

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Correo Científico Médico 2012; 16 (4)

Histopathology of Bulbar Mucosa in Patients with Duodenal Ulcer and Chronic Antral Gastritis by Helicobacter pylori

Gámez EMM, Mulet PA, Pozo AH, Verdecia CAM

Language: Spanish
References: 23
Page:
PDF size: 952.11 Kb.


ABSTRACT

Bacground: it is known on the association between Helicobacter pylori infection and the presence of duodenal but its pathogenesis is unknown. There are no publications in this context to describe the histopathology of the bulbar mucosa associated to duodenal ulcer, and its relationship to chronic antral gastritis by Helicobacter pylori, which could provide elements on the disease pathogenesis. Objectives: to estimate the bulbar mucosa histic changes in patients with duodenal ulcer and chronic antral gastritis by Helicobacter pylori and identify a possible relationship between the magnitude of both histopathological and density of colonization. Methods: a descriptive study in 39 patients with endoscopic diagnosis of duodenal ulcer and chronic antral gastritis by Helicobacter pylori, two antral gastric biopsies and two of bulbar mucosa, between January 2008 and January 2009 at Vladimir Ilich Lenin University Hospital was carried out. Results: chronic acute bulbitis predominated, patients with bulbitis chronic active in 27 patients (69.2%) on the bulbitis with metaplasia, exulceration and colonization by Helicobacter pylori, 10 (25.7%). Antral predominant active chronic gastritis, moderate, and abundant colonization density, no significant relationship with the bulbitis with or without metaplasia predominated. Conclusions: the prevalence of chronic active bulbitis on bulbitis with metaplasia could be due to the existence of more than one pathogenic mechanism for Helicobacter pylori in duodenal ulcer. Active chronic antral gastritis, severe, with abundant colonization dominated the bulbitis with gastric metaplasia, no significant association between the magnitudes of the bulbitis histopathological and antral gastritis which could be due to other factors.


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