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2011, Number 4

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Rev Med MD 2011; 2.3 (4)

Role of apoptosis in the antitumor immune response

García-Castro B, Olimón- Andalón V, Aguilar-Lemarroy A

Language: Spanish
References: 42
Page: 206-210
PDF size: 564.70 Kb.


ABSTRACT

Apoptosis is a programmed cell death finely regulated, essential in the tissue homeostasis maintenance since it is in charge of eliminating those unnecessary or harmful organism cells. The defects in the apoptotic signaling pathway promote the abnormal cell proliferation and genetic defects accumulation, leading to tumorigenesis and frequently bestows resistance to the chemotherapeutic drugs upon the cancerous cells. Due to these reasons, the apoptosis regulation is fundamental to maintain the balance between survival signaling and cell death required for the prevention of diseases. Many signaling pathways regulate the induction or inhibition of apoptosis, the main regulator proteins are the BCL-2, inhibitors of apoptosis (IAP) and the c-FLIP protein. This review will point out the mechanisms by which these proteins regulate the apoptosis; moreover, provide further explanations to the most frequently observed alterations in the inhibition of apoptotic signaling.


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