Ochoa-Hernández AB, Jave-Suárez LF

Idioma: Español
Referencias bibliográficas: 37
Paginas: 211-215
Archivo PDF: 563.82 Kb.

RESUMEN

La vía WNT (Wingless «Wg» en Drosophila melanogaster) desempeña un papel fundamental en la diferenciación celular y en la morfogénesis de órganos y tejidos. Desde hace algunos años, se han acumulado evidencias de la intervención de esta vía en el desarrollo de las células del sistema inmune, especialmente de linfocitos T y B. Muchos estudios han delineado los mecanismos por los que esta vía ejerce regulación en la inflamación y en el control de la proliferación y la apoptosis celular, por lo que las variaciones en los mecanismos de señalización de ésta, darán lugar a anomalías funcionales, alteraciones en la organización celular y al desarrollo de patologías. En esta revisión se describirán brevemente los eventos relevantes de la participación de la vía WNT en el desarrollo del sistema inmune y la respuesta inflamatoria.

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