2011, Number 5
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Rev Med Inst Mex Seguro Soc 2011; 49 (5)
Differences in spermatic morphology between couples with repeated pregnancy loss and infertility
Carranza-Lira S, Celis-Rico GJ
Language: Spanish
References: 13
Page: 523-526
PDF size: 28.74 Kb.
ABSTRACT
Objective: to determine the differences in sperm morphology between couples who never have been pregnant and those with habitual early pregnancy loss.
Methods: forty five infertile couples were divided into two groups as follow: if they have never been pregnant or if they had habitual miscarriage. Women’s and men’s ages, as well as time of infertility were investigated. A semen analysis was done to all male partners and the following parameters were analyzed: Concentration, agglutination, viscosity, motility, morphology and leukocytes presence. For analysis three cutoff points were used, considering if they had two or more miscarriages, three or more or 4 or more. Data are reported in median and range. Comparison among the groups was made by Mann-Whitney
U test and Chi square.
Results: when comparing the couples with two or more miscarriages, with those with no pregnancy, no differences were found. When the cutoff point was three or more miscarriages, also no differences were found. When cutoff point was four or more miscarriages, only normal morphology was statistically greater in group with no previous pregnancy than in group with habitual miscarriage 47 (16-93) and 36 (4-40), respectively,
p ‹ 0.04).
Conclusions: low normal sperm morphology is associated with repeated early pregnancy loss.
REFERENCES
Kruger TF, Menkveld R, Stander FSH, Lombard CJ, van der Merwe JP, van Zyl JA, et al. Sperm morphologic features as a prognostic factor in in vitro fertilization. Fertil Steril 1986;46:1118-1123.
Oehninger SC, Kruger TF, Simon T, Jones D, Mayer J, Lanzendorf SL, et al. A comparative analysis of embryo implantation potential in patients with severe teratozoospermia undergoing in vitro fertilization with a high insemination concentration or intracytoplasmic sperm injection. Hum Reprod 1996;11:1086-1089.
De Vos A, van de Helde H, Joris H, Verheyen G, Devroey P, van Steirteghem A. Influence of individual sperm morphology on fertilization, embryo morphology and pregnancy outcome of intracytoplasmic sperm injection. Fertil Steril 2003;79:42-48.
Salumets A, Suikkari AM, Möls T, Söderström-Anttila V, Tuuri T. Influence of oocytes and spermatozoa on early embryonic development. Fertil Steril 78;5:1082-1087.
Hill JA, Abbot AF, Politch JA. Sperm morphology and recurrent abortion, Fertil Steril 1994;61:776-778.
Lee JD, Kamiguchi Y, Yanagimachi R. Analysis of chromosome constitution of human spermatozoa with normal and aberrant head morphologies after injection into mouse oocytes. Hum Preprod 1996;11:1942-1946.
Rosenbusch B, Sterzik K. Sperm chromosomes and habitual abortion. Fertil Steril 1991;56:370-372.
Burr RW, Wang XJ, Siegberg R, Matthews CD, Flaherty SP. The influence of sperm morphology and the number of otile sperm inseminated on the outcome of intrauterine insemination combined with mild ovarian stimulation. Fertil Steril 1996;65:127-132.
Strandell A, Bergh C, Söderlund B, Lundin K, Nilsson L. Fallopian tube sperm perfusion: the impact of sperm count and morphology on pregnancy rates. Acta Obstet Gynecol Scand 2003;82:1023-1029.
Karabinus DS, Gelety TJ. The impact of sperm morphology evaluated by strict criteria on intrauterine insemination success. Fertil Steril 1997;67:536-541.
Van Waart J, Kruger TF, Lombard CJ, Ombelet W. Predictive value of normal sperm morphology in intrauterine insemination (IUI): a structured literature review. Hum Reprod Update 200;7:495-500.
Donnelly ET, Lewis SEM, McNally JA, Thompson W. Fertil Steril 1998;70:305-314.
Lundin K, Söderlund B, Hamberger L. The relationship between sperm morphology and rates of fertilization, pregnancy and spontaneous abortion in an in-vitro fertilization/ intracytoplasmatic sperm injection programme. Hum Reprod 1997;12:2676-2681.