medigraphic.com

2012, Number 1

<< Back Next >>

Rev Med Inst Mex Seguro Soc 2012; 50 (1)

New trends in macrophages, inflammation and adipose tissue

Rico-Rosillo MG, Vega-Robledo GB

Language: Spanish
References: 55
Page: 39-45
PDF size: 99.01 Kb.


ABSTRACT

Obesity is considered a low-inflammatory condition. An increasing number of reports suggest that the adipose tissue itself might be a source of proinflammatory factors and a target of inflammatory processes. Accumulating evidence suggest the involvement of adipose tissue derived proteins, collectively known as adipokines as well as other factors produced in this tissue by cells besides to adipocytes, like fibroblasts, lymphocytes and macrophages. The burden of obesity on health extends across multiple organs systems and diseases (atherosclerosis, coronary heart diseases, osteoarthritis, diabetes, hypertension, dyslipidemia). The high incidence and its chronic inflammatory condition have had a wide impact. The chronic nature of obesity produces a tonic low-grade activation of the innate immune system that affects steady-state measures of metabolic homeostasis over time. In this review we highlight the macrophage participation in the generation of obesityinduced inflammation.


REFERENCES

  1. Moreno-Aliaga MJ, Santos JL, Marti A, Martínez JA. Does weight loss prognosis dependo n genetic make-up? Obes Rev 2005;6:155-168.

  2. Sánchez-Castillo CP, Pichardo-Ontiveros E, López P. Epidemiología de la obesidad. Gac Med Mex 2004;140(2):3-20.

  3. Torres-Márquez ME. Invitación a considerar la lucha contra la obesidad y no contra el obeso. Rev Ed Bioquim 2006;25 (2):39-40.

  4. Gutiérrez-Fisac JL. La obesidad: una epidemia en curso. Med Clin 1998;111(12):456-458.

  5. Feng J, Glass TA, Curriero FC, Stewart WF, Schwartz BS. The built environment and obesity: a systematic review of the epidemiologic evidence. Health & Place 2010; 16:175-190.

  6. Bastard JP, Maachi M, Tran Van Nhieu J, Jardel C, Bruckert E, Grimaldi A, et al. Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro. J Clin Endocrinol Metab 2002;87:2084- 2089.

  7. Hotamisligil GS, Shargil NS, Spiegelman BM. Adipose expression of tumor necrosis factor-β: direct role in obesity- linked insulin resistance. Science 1993;259:87-91.

  8. Kahn SE, Zinman B, Haffner SM, O’Neill MC, Kravitz BG, Yu D, et al. Obesity is a major determinant of the association of C-reactive protein levels and the metabolic syndrome in type 2 diabetes. Diabetes 2006;55:2357-2364.

  9. Kim CS, Park HS, Kawada T, Kim JH, Lim D, Hubbard NE, et al. Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and associated with obesity- related parameters. Int J Obes 2006;30:1347-1355.

  10. Cancello R, Henegar C, Viguerie N, Taleb S, Pitou C, Rouault C, et al. Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgeryinduced weight loss. Diabetes 2005;54:2277-2286.

  11. Cancello R, Tordjman J, Poitou C, Guilhem G, Bouillot JL, Hugol D, et al. Increased infiltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesity. Diabetes 2006; 55:1554-1561.

  12. Curat CA, Wegner V, Sengenes C, Miranville A, Tonus C, Busse R, et al. Macrophages in human visceral adipose tissue: increased accumulation in obesity and a source of resistin and vifastin. Diabetologia 2006;49:744-747.

  13. Zeyda M, Farmer D, Todoric J, Aszmann O, Speiser M, Györi G, et al. Human adipose tissue macrophages are of an anti-inflammatory phenotype but capable of excessive proinflammatory mediator production. Int J Obes 2007; 31(9):1420-1428.

  14. Harman-Boehm I, Bluher M, Redel H, Sion-Vardy N, Ovadia S, Avinoach E, et al. Macrophage infiltration into omental versus subcutaneous fat across different populations: effect of regional adiposity and the co-morbidities of obesity. J Clin Endocrinol Metab 2007;92(6):2240-2247.

  15. De Luca C, Olefsky J. Inflammation and insulin resistance. FEBS Lett 2008;582:97-105.

  16. Trayhurn P, Wang B, Wood IS. Hipoxia in adipose tissue: a basis for the dysregulation of tissue function in obesity. Br J Nutr 2008;100(2):227-235.

  17. Curat CA, Miranville A, Sengenes C, Diehl M, Tonus C, Busse R, et al. From blood monocytes to adipose tissueresident macrophages: induction of diapedesis by human mature adipocytes. Diabetes 2004;53:1285-1292.

  18. Poglio S, De Toni-Costes F, Arnaud E, Laharrague P, Espinosa E, Casteilla L, et al. Adipose tissue as a dedicated reservoir functional mast cell progenitors. Stem Cell 2010; 28(11):2065-2072.

  19. Azurek TM, Zhang LF, Zalewski A, Mannion J, Eiehl J, Arafat H, et al. Human epicardial adipose tissue is a source of inflammatory mediators. Circulation 2003;108: 2460-2466.

  20. Lynch L, O’Shea D, Winter DC, Geoghegan J, Doherty DG, O’Farrelly C. Invariant NKT cells and CD1d (+) cells amass in human omentum and are depleted in patients with cancer and obesity. Eur J Immunol 2009;39(7):1893- 1901.

  21. Weisberg SP, McCann D, Desai M, Rosembaum M, Leibel RL, Ferrante AW Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003; 112:1796-1808.

  22. Xu H, Barnes HT, Yang Q, Ta G, Yang D, Chou CJ, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 2003, 112:1821-1830.

  23. Mohanty P, Aljada A,Ghanim H, Hofmeyer D, Tripathy D, Syed T, et al. Evidence for a potent anti-inflammatory effect of rosiglitazone. J Clin Endocrinol Metab 2004;89: 2728-2735.

  24. Bruun JM, Lihn AS, Pedersen SB, Richelsen B. Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue (AT): implication of macrophages resident in the AT. J Clin Endocrinol Metab 2005;90:2282-2289.

  25. Sartipy P, Loskutoff DJ. Monocyte chemo-attractant protein 1 in obesity and insulin resistence. Proc Natl Acad Sci 2003;100:7265-7270.

  26. Kurihara T, and Bravo R. Cloning and functional expression of mCCR2, a murine receptor for C-C chemokines JE and FICS. J Biol Chem 1996;271:11603-11607.

  27. McQuiban GA, Gong JH, Tam EM, McCulloch CA, Clark- Lewis I, Overall CM. Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3. Science 2000;289:1202-1206.

  28. Ingersoll M, Platt A, Polteaux S, Randolph S. Monocyte trafficking in acute and chronic inflammation. Trends in Immunol 2011; [Epub ahead of print].

  29. Charo JF, and Peters W. Chemokine receptor 2 (CCR2) in atherosclerosis, infectious diseases, and regulation of T-cell polarization. Microcirculation 2003;10:259-264.

  30. Tabata T, Mine S, Kawahara C, Okada Y, Tanaka Y. Monocyte chemoattractant protein-1 induces scavenger receptor expression and monocyte differentiation into foam cells. Biochem Biophys Res Commun 2003;305(2):380-385.

  31. Takaishi H, Taniquchi T, Takahashi A, Ishikawa Y, Yokoyama M. High glucose accelerates MCP-1 production via p38 MAPK in vascular endothelial cells. Biochem Biophys Res Commun 2003;305(1):122-128.

  32. Weisberg SP, Hunter D, Huber R, Lemieux J, Slaymaker S, Vaddi K, et al. CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest 2006;116:115-124.

  33. Brodmerkel CM. Discovery and pharmacological characterization of a novel rodent active CCR2 antaginist, INCB3344. J Immunol 2005;175:5370-5378.

  34. Kolonin MG, Saha PK, Chan L, Pasqualini R, Arap W. Reversal of obesity by targeted ablation of adipose tissue. Nat Med 2004;10:625-632.

  35. Lacasa D, Taleb S, Keophiphath M, Miranville A, Clement K. Macrophage-secreted factors impair human adipogenesis: involvement of proinflammatory state in preadipocites. Endocrinology 2007;148:868-877.

  36. Lumeng CN, Deyoung SM, Bodzin JL, Saltill AR. Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes 2007;56(1): 16-23.

  37. Heilbronn LK, and Campbell LV. Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity. Curr Pharm Des 2008;14(12):1225- 1230.

  38. Prins JB. Adipose tissue as an endocrine organ. Best Pract Res Clin Endocrinol Metab 2002;16(4):639-651.

  39. Spiegelman BM, Enerbäck S. The adipocyte: a multifunctional cell. Cell metab 2006;4(6):425-427.

  40. Rajalá MW, and Scherer PE. Minireview: The adipocyte at the crossroad of energy homeostasis, inflammation, and atherosclerosis. Endocrinology 2003;144(9):3765-3773.

  41. Wellen KE and Hotasmiligil GS. Inflammation, stress, and diabetes. J Clin Invest 2005;115:1111-1119.

  42. Antuna-Puente B, Feve B, Fellahi S, Bastard JP. Adipokines: the missing link between insulin resistance and obesity. Diabetes Metab 2008;34(1):2-11.

  43. Fain JN, Madan AK, Hiler ML, Cheema P, Bahouth SW. Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans. Endocrinology 2004;145(5):2273-2282.

  44. Ito Y, Daitoku H, Fukamizu A. Foxo 1 increases proinflammatory gene expression by inducing C/EBPbeta in TNFalpha- treated adipocytes. Biochem Biophys Res Commun 2009;378(2):290-295.

  45. Bruun JM, Pedersen SB, Kristensen K, Richelsen B. Effects of proinflammatory cytokines and chemokines on leptin production in human adipose tissue in vitro. Mol Cell Endocrinol 2002;190:91-99.

  46. Dandona P, Aljada A, Bandyopadhyay A. Inflammation: the link between insulin resistance, obesity and diabetes. Trends Immunol 2004;25(1):4-7.

  47. Gruen ML, Hao M, Piston DW, Hasty AH. Leptin requires canonical migratory signaling pathway for induction of monocyte and macrophage chemotaxis. Am J Physiol Cell Physiol 2007;293(5):1481-1488.

  48. Fantuzzi G. Three questions about leptin and immunity. Brain Behavior Immun 2009;23:405-410.

  49. Vilarrasa N, Vendrell J, Maravall J, Broch M, Estepa A, Megia A, et al. Distribution and determinants of adiponectin, resistin, and ghrelin in a randomly selected healthy population. Ciln Endocrinol 2005;63(3):329-335.

  50. Fukuhara A, Matsuda M, Nishizawa M, Segawa K, Tanaka M, Kishimoto K, et al. Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science 2005; 307(5708):426-430.

  51. Yamawaki H, Hara N, Okada M, Hara Y. Visfatin causes endothelium-dependent relaxation in isolated blood vessels. Biochem Biophys Res Commun 2009;383(4):503-508.

  52. Ukkola O. Resistin a mediated of obesity-associated insulin resistance or an innocent bystander? Eur J Endocrinol 2002; 147: 571-574.

  53. Shuldiner AR, Yang R, Gong DW. Resistin, obesity and insulin resistance the emerging role of the adipocyte as an endocrine organ. N Engl J Med 2001;345:1345-1346.

  54. Sheng CH, Di J, Jin Y, Zhang YC, Wu M, Sun Y, et al. Resistin is expressed in human hepatocytes and induces insulin resistance. Endocrine 2008;33(2):135-143.

  55. Hosada H, Kojima M, Mitzushima T, Shimizu S, Kangawa K. Structural divergence of human ghrelin. Identification of multiple ghrelin-derived molecules produced by posttranslational processing. J Biol Chem 2003;278:67-70.




2020     |     www.medigraphic.com