2011, Number 6
Recombinant human TSH in pediatric thyroid cancer
Language: Spanish
References: 8
Page: 665-667
PDF size: 29.10 Kb.
ABSTRACT
The treatment of pediatric thyroid cancer usually includes thyroid surgery, therapeutic radioactive iodine ablation and TSH suppression with levotiroxine. Thyroid hormone withdrawal in the usual follow-up of thyroid cancer has adverse effects on patients. Rh TSH has the advantage of avoiding both hypothyroidism, with a major impact on the patient’s quality of life, and the side effects on tumor growth related to the long-lasting TSH increase. Rh TSH has proven to be effective and safe, but the majority of publications are based on adult population. In this report we present our experience with the administration of rh TSH in the diagnostic evaluation for treatment in a series of four cases of thyroid cancer in children. In all cases we observed clinical benefits without secondary effects. In conclusion rh TSH is an appropriate treatment option for the disease and represents a valuable alternative to thyroxin withdrawal.REFERENCES
American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer; Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, et al. Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 2009;19(11):1167-1214.
Luster M, Handkiewicz-Junak D, Grossi A, Zacharin M, Taïeb D, Cruz O, et al. Recombinat thyrotropin use in children and adolescents with differentiated thyroid cancer: a multicenter retrospective study. J Clin Endocrinol Metab 2009;94(10):3948-3953. Disponible en http://jcem. endojournals.org/content/94/10/3948.full.pdf+html