Cervera-Castillo H, Cajigas-Melgoza JC, Ventura-Ríos L, Torres-Caballero V, Prieto-Parra RE, García-Cervantes ML, Hernández-Quiroz MC, Vera-Lastra O

Language: Spanish
References: 37
Page: 591-598
PDF size: 109.19 Kb.

ABSTRACT

Background: relapsing polychondritis (RP) is a rare multisystem disease of unknown etiology, characterized by recurrent episodes of inflammation and cartilage destruction. The aim was I to present fifteen cases, analyzed in a clinical and therapeutic perspective.
Methods: fifteen cases from three different cities of Mexico, diagnosed with Damiani criteria were included. Clinical features, treatment given and outcome were recorded.
Results: nine men and six women with mean age of 52.4 years met the criteria for RP; the average change was 86.7 months. The dominant clinical manifestations were: 83 % auricular chondritis, 66 % dysphonia, 60 % arthritis and 53 % with eye involvement. Treatment included: 93 % corticosteroids, 60 % methotrexate, and 46 % no steroidal anti-inflammatory, 46 % immunosuppressant, and biologic therapy in two cases. The clinical course showed 34 relapses in twelve cases. Complications included hoarseness in seven cases, six tracheal stenosis, and hearing loss in three cases. There were five deaths, three by respiratory complications, one by renal failure and another with a cerebral vascular event.
Conclusions: the fifteen cases with RP presented characterized by multisystem clinical courses, serious respiratory complications, and diagnostic and therapeutic resources merited highly medical specialized approachment.

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