Lastra CG, Soriano RJ, Carrera GE, Guevara LB, Durán PMA

Language: Spanish
References: 12
Page: 164-167
PDF size: 126.58 Kb.

ABSTRACT

A 20 year old woman presented with symmetrical lower limb edema and abdominal enlargement, the physical exam revealed jaundice and ascites. Laboratory results included positive VDRL test and circulating antiphospholipid antibodies (aPL). The patient developed progressive respiratory failure and died. The autopsy revealed inferior vena cava and hepatic vein thrombosis, a mural thrombi in the right atrium, left pulmonary artery thrombi and an old pulmary infarction in the same side. Budd-Chiari syndrome secondary to primary antiphospholipid syndrome was established, since no other autoimmune or connective tissue disease was found. The hepatic complications of the antiphospholipid syndrome includes Budd-Chiari syndrome, veno-oclussive disease, nodular regenerative hyperplasia, transient elevation of liver enzymes and infarction. The pathogenesis of the thrombosis is not well understood. Some authors thought that antiphospholipid syndrome is the second cause of non-tumorous Budd-Chiari syndrome.

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