2012, Number 6
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Bol Med Hosp Infant Mex 2012; 69 (6)
Current role of —and new evidence for—continuous positive airway pressure in respiratory distress syndrome
Osorno CL
Language: Spanish
References: 51
Page: 422-430
PDF size: 216.88 Kb.
ABSTRACT
Mechanical ventilation and early or prophylactic surfactant has been
the standard of care for many years in neonates with respiratory
distress syndrome (RDS). The evidence for this practice is supported
in metaanalysis of well-controlled clinical trials. Observational studies
showed by the end of the 1980s that perinatal centers that used
continuous positive airway pressure (CPAP) as the primary method
of ventilatory support had a lower rate of bronchopulmonary dysplasia
and used less ventilation for their neonates. Lack of more solid
evidence has been one of the reasons for which this method of care
of RDS has remained restricted to few perinatal centers worldwide.
Randomized multicenter clinical trials carried out during the last decade
in very low birth weight neonates, which compare prophylactic
or early nasal CPAP vs. mechanical ventilation with prophylactic
or selective surfactant with early or programmed extubation, were
reviewed.
Recent clinical trials enable us to assert that early nasal CPAP is
an alternative to intubation, and surfactant in the delivery room
diminishes the need for mechanical ventilation, use of surfactant
and steroids for bronchopulmonary dysplasia. A low threshold for
surfactant in neonates supported early with CPAP diminishes the
need for mechanical ventilation.
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