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2012, Number 1

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Rev Med MD 2012; 3.4 (1)

A second skin: Skin replacement treatment

Álvarez LJA, Flores OM, Hernández GRI, Martínez MHR, Escamilla OCE, Rivera SG

Language: Spanish
References: 20
Page: 37-41
PDF size: 688.63 Kb.


ABSTRACT

Skin substitutes (SS) constitute an effective treatment in situations in which skin is destroyed, such as skin burns that compromise more than 60% of total body surface, traumatic injuries and genetic diseases that can damage the skin resulting in chronic wounds. In contrast with skin autografts, that require a certain amount of the patient´s healthy tissue to be available, skin substitute grafts can be obtained from other human beings, animals or be created in a laboratory. Biological and synthetic skin substitutes are available. The first ones are more economically accessible and abundant, none the less synthetic substitutes have shown to have more specific qualities in patient treatment, in spite of lacking organic elements and basement membrane. Between the most popular skin substitutes available we can find: TranCyte®, Biobrane®, Kollagen®, Matriderm®, Alloderm®, Apligraf®, Dermagraft® and Integra®, being this last one the most widely accepted. Ideally, a skin substitute should be durable, elastic, non-permeable to water, available and non-antigenic, resulting in optimal treatment of the patient with skin injuries. Limitations must be taken into account when choosing a skin substitute, such as cost, availability, quality and patient´s predicted acceptance of the graft. Biotechnological advances of these substitutes are encouraging, resulting in quality improvement and lowering the economic burden of the cost.


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