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Revista de la Asociación Médica del Centro Médico ABC

2012, Number 3

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An Med Asoc Med Hosp ABC 2012; 57 (3)

Oxidative stress in the perinatal period

Cortina RM, Arizmendi-Dorantes JG

Language: Spanish
References: 28
Page: 217-222
PDF size: 44.76 Kb.


ABSTRACT

Oxygen participates importantly in the energy cycle of living beings is essential in cell respiration in aerobic organisms. Oxidative stress is a consequence of disruption of the balance between oxidants and antioxidants with a shift in favor of the former. During fetal life, the partial pressure of oxygen (PaO2) is 25-30 mmHg, this state of relative hypoxemia allows fetal growth and normal differentiation. Excess oxygen can alter the balance between free radicals and antioxidant systems, which can cause damage in the synthesis of proteins, lipids and nucleic acids, with serious consequences in the short and long term. In this work of literature review we show the physiopathology of the injury by oxidative stress in the perinatal period and its clinical implications, with the purpose to draw the attention of the paediatricians for a more rational use of oxygen.


REFERENCES

  1. Mckee T, Mackee JR. La base molecular de la vida. Bioquímica. 3a edición, Madrid: Mc Graw-Hill/Interamericana; 2005: 236-240.

  2. Sies H, Jones DP. Oxidative stress. In: Fink G. Encyclopedia of stress, San Diego, CA: Ed. Elsevier; 2007; 3: 45-48.

  3. Schafer F, Buettner G. Redox environment of the cell as viewed on through the redox stage of the glutathione disulfide/glutathione couple. Free Rad Biol Med 2001; 30: 1191-1212.

  4. Guyton AC, Hall JE. Tratado de fisiología médica. 12a Edición; España: Editorial Elsevier; 2011: 561-565.

  5. Stephens NG et al. Randomized controlled trial of vitamin E in patients with coronary disease: Cambridge heart antioxidant study (CHAOS). Lancet 1996; 347: 781-786.

  6. Northway WH, Rezeau L Jr, Petriceks, Bensch KG. Oxygen Toxicity in the Newborn Lung: Reversal of Inhibition of DNA Synthesis in the Mouse Pediatrics 1976; 57: 141-146.

  7. Vento M. Tritrating oxygen needs in the very preterm newborn in the delivery room. J Neonat Perinat Med 2010; 3: 161-169.

  8. Kelly FJ. Free radical disorders of preterm infants. Br Med Bull 1993; 49 (3): 668-678.

  9. Vento M. Oxidative stress in asphyxiated term infants resuscitated with 100% oxygen. J Pediatr 2003; 142: 240-246.

  10. Tan A, Schulze A, O’Donnell CP, Davis PG. Air versus oxygen for resuscitation of infants at birth. Cochrane Database Syst Rev 2005; 2: CD002273.

  11. Saugstad OD, Ramji S, Vento M. Resuscitation of depressed newborn infants with ambient air or pure oxygen: a meta-analysis. Biol Neonate 2005; 87 (1): 27-34.

  12. Saugstad OD, Ramji S, Irani SF, El-Meneza S, Hernández EA, Vento M, Talvik T, Solberg R, Rootwelt T, Aalen OO. Resuscitation of newborn infants with 21 or 100% oxygen: follow-up at 18 to 24 months. Pediatrics 2003; 112 (2): 296-300.

  13. Askie LM, Henderson-Smart DJ, Ko H. Restricted versus liberal oxygen exposure for preventing morbidity and mortality in preterm or low birth weight infants. Cochrane Database Syst Rev 2009; 1: CD001077.

  14. Eber E, Zach MS: Long term sequelae of bronchopulmonary dysplasia (chronic lung disease of infancy). Thorax 2001; 56: 317-323.

  15. Uauy R, Fanaroff A, Konmes Sh, Philips J, Wright L. Necrotizing enterocolitis in very low birth weight infants: Biodemographic and clinical correlates. J Pediatr 1991; 119: 630-638.

  16. Hammerman C, Kaplan M. Patent ductus arteriosus in the premature neonate. Current concepts in pharmacological management. P Drugs 1999; 1: 81–92.

  17. Schouman-Claeys E, Frija G, Delaveaucoupet J et al. Evaluation parIRM des leucomalacies périventriculaires au période post-natale précoce. Rev Int Pediatr 1989; 190: 32-33.

  18. Barkovich AJ. Pediatric neuroimaging. New York: Raven Press, 1990: 49-52.

  19. Kattwinkel J editor. American Heart Association. Manual de reanimación neonatal. Academia Americana de Pediatría. 5ª Edición, Editorial American Heart Association 2006: 3-17.

  20. Jobe AH, Bancalari E. Bronchopulmonary dysplasia. NICHD/NHLBI/ORD workshop summary. Am J Respir Crit Care Med 2001; 163: 1723-1729.

  21. Sola A. Turn off the lights and the oxygen, when not needed: phototherapy and oxidative stress in the neonate. J Pediatr (Rio J). 2007; 83 (4): 293-296.

  22. Sola A, Rogido M. Iron, oxidant injury, and practice choices in preterm infants. J Pediatr 2008; 152 (2): 295-296.

  23. Saugstad OD, Ramji S, Rootwelt T, Vento M. Response to resuscitation of the newborn: early prognostic variables. Acta Paediatr 2005; 94: 890-895.

  24. Bouzas L, Bauer G, Novali L, Dilger A, Galina L, Falbo J, Díaz GL, Manzitti J, Sola A. Retinopathy of prematurity in the XXI century in a developing country: an emergency that should be resolved. An Pediatr (Barc) 2007; 66 (6): 551-558.

  25. Grupo de Trabajo Colaborativo Multicéntrico para la Prevención de la Ceguera en la Infancia por Retinopatía del Prematuro. Recomendación para la pesquisa de retinopatía del prematuro en poblaciones de riesgo. Arch Argent Pediatr 2008; 106 (1): 71-76.

  26. Davis PG, Tan A, O’Donnell CP, Schulze A. Resuscitation of newborn infants with 100% oxygen or air: a systematic review and meta-analysis. Lancet 2004; 364: 1329-1333.

  27. Neil Finer. Use of oxygen for resuscitation of the extremely low birth weight infant. Pediatrics 2010; 125 (2): 389-391.

  28. Saugstad OD, Aune D. In search of the optimal oxygen saturation for extremely low birth weight infants: a systematic review and meta-analysis. Neonatology 2011; 100 (1): 1-8.z




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