Arroyo FAP, Ortega CML

Language: Spanish
References: 26
Page: 191-198
PDF size: 84.45 Kb.

ABSTRACT

Soft-tissue fillers are generally used to plump furrows and hollows in the face, reduce wrinkles and give the skin a smoother and more youthful-looking appearance. They also are very effective at contouring specific areas on the face, such as around the lips and mouth, and can correct depressions and scars. Filler substances include collagen, self-donated fat, hyaluronic acid, hydroxyapatite, polymethylmethacrylate (PMMA), poly-lactic acid, and polymer implants. Objective: To use a new choice TRIMPLANT^MR to reverse aging changes and attempt to achieve an acceptable facial rejuvenation. Materials and methods: An experimental study, which included 25 patients, considering age 30-60 years, gender (female o male), type of defect, and overall looking for improvement of the facial aspect. Results: A total of 25 patients were included, the average age was 46 years old, 88% female. The most frequent defect was at the nasolabial fold. We found a significant statistical difference for the change at the nasolabial fold and interciliar defect (p ‹ 0.001).The difference in the lesion depth was: (2.4 mm) and after (1.17 mm). There was no substantial difference in periorbital defect or corners. Conclusions: The volume restauration is a very important aspect in facial rejuvenation, the obtained results of this research shows a promising and statistically significant improvement in the ritides and deep furrows.

REFERENCES

1. Goldsmith LA. Biochemistry and physiology of the skin. 2nd. Ed. New York: Oxford University Press; 1991: 3-16.

2. Bentkover SH. The biology of facial fillers. Facial Plast Surg 2009; 25 (2): 73-85.

3. Sánchez-Carpinteiro I, Candelas D, Ruíz-Rodríguez R. Materiales de relleno: tipos, indicaciones y complicaciones. Actas Dermo-Sifiliográficas 2010; 101 (5): 381-393.

4. Pollack S. Silicone, fibres and collagen implantation for facial lines and wrinkles. J Dermatol Surg Oncol 1990; (16): 957-961.

5. Gladstone HB, Cohen JL. Adverse effects when injecting facial fillers. Semin Cutan Med Surg 2007; (26): 34-39.

6. Dadzie OE, Mahalingan M, Parada M, El Helou T, Philips T, Bhawan J. Adverse cutaneous reactions to soft tissue fillers- a review of the histological features. J Cutan Pathol 2008; 35 (6): 536-548.

7. Oleniun M. The first clinical study using a new biodegradable implant for the treatment of lips, wrinkles, and folds. Aesthetic Plast Surg 1998; (22): 97-101.

8. Barry LE, Summerlín DJ, Sadove AM. A potential biomaterial composite for dermal and subcutaneous augmentation. Ann Plast Surg 1994; 32 (5): 463-468.

9. Sclafani A, Romo T, Silver L. Clinical and histologic behavior of exposed porous high-density polyethylene implants. Plast Reconstr Surg 1997; 99: 41-50.

10. Tromavitch T, Stegman S, Glogau R. Zyderm collagen: Implantation techniques. J Am Acad Dermatol 1984; (10): 273-278.

11. Miller E. Isolation & characterization of collagen from chick cartilage containing three identical chains. J Biochemistry 1971; 10 (9): 1652-1659.

12. Flesh P. The cementing substance of the human homy layer. J Soc Cos Chem XIII 1962; 3: 113.

13. Krötzsch-Gómez FE. Efecto del fibroquel sobre el metabolismo de la colágena en cultivos celulares de fibroblastos y macrófagos de ratas [Tesis de maestría]. D.F., México. UNAM, 1995.

14. Furuzawa-Carballeda J, Rojas E, Valverde M, Castillo I, Díaz de León L, Krötzsch E. Cellular and humoral responses to collagen-polivinilpirrolidone administered during short and long periods in humans. Can J Physiol Pharmacol 2003; 81 (11): 1029-1035.

15. Krötzsch FE. Método modificado para la extracción de colágena nativa a partir de piel de ovino nonato [Tesis de licenciatura]. D.F., México. Facultad de Química, UNAM, 1992.

16. Mukhtar H. Pharmacology of the skin. London: CRC Press; 1992: 284-293.

17. Nickoloff BJ. Dermal immune system. In: Boca Raton, FL: CRC Press; 1993: 1-164.

18. Millikan L et al. A multicenter study treatment of depressed cutaneous scars with gelatin matrix implant. J Am Acad Dermatol 1987; 16: 1155-1162.

19. Krötzsch-Gómez FE, Furuzawa-Carballeda J, Reyes-Márquez R, Quiroz-Hernández E, Díaz de León L. Cytokine expression is downregulated by collagen-polyvinylpyrrolidone in hyperthophic scars. J Invest Dermatol 1998; (111): 828-834.

20. Krötzsch FE. Análisis del efecto de la colágena-polivinilpirrolidoma sobre la expresión in vitro de algunos medidores solubles que participan en el metabolismo de la colágena [Tesis de doctorado]. D.F., México. UNAM, 1999.

21. Robinson BV PVP. A critical review of the kinetics and toxicology of polivinilpirrolidone (Povidone). In: Chelsea MI: Lewis Publishers; 1990: 7-52.

22. United States. Congress House. Committee on Interstate and Foreign commerce. Subcommittee on Oversight and Investigations. Safety of hair dyes and cosmetic products: hearing before the Subcommittee on Oversight and Investigations of the Committee on Interstate and Foreign Commerce, House of Representatives, Ninety-sixth Congress, first session, July 19, 1979. Squalene. Expert Panel Evaluation. Washington: US Govt. Print. Off., 1979 i.e. 1980.

23. Misihi KN et al. Biomedical applications of chromatographic fraction containing trehalose dimycolate in squalane emulsion. J Cromatogr 1998; 25 (440): 473-478.

24. Hilgers LA, Platenburg PL, Luitjens A, Groenveld B, Dazelle T, Weststrate MW. A novel non-mineral oil-based adjuvant II. Efficacy of a synthetic sulfolipopolysaccharide in a squalane-in-water emulsion in pigs. Vaccine 1994; 12 (7): 661-665.

25. Kamimura H, Nobuyuki K, Kazuta O, Hisertoshi Y. Enhanced elimination of theophylline, phenobarbital and strychnine from the bodies of rats and mice by squalane treatment. J Pharmacobiodyn 1992; 15 (5): 215-221.

26. Kamimura H, Koga N, Oguri K, Yoshimura H, Inoue H, Sato K, Ohkubo M. Studies on distribution and excretion of squalane in dogs administered for 2 weeks. Fukuoka Igaku Zasshi 1991; 80 (5): 300-304.