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2012, Number 4

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Evid Med Invest Salud 2012; 5 (4)

Vibrio cholerae cytolysin (VCC) toxin: from vacuolization to cell death

Castañón-Sánchez CA

Language: Spanish
References: 43
Page: 114-119
PDF size: 238.45 Kb.


ABSTRACT

Epidemic cholera caused by toxigenic Vibrio cholerae belonging to serogroups O1 and O139 is a serious public health problem in many developing countries. The disease is characterized by an acute dehydrating diarrhea caused mainly by cholera toxin, enterotoxin produced by these microorganisms during the pathogenesis of the disease. In its severe form, patients even present hypovolemic shock, acidosis and death if treatment in not started in time. Two distinct epidemiological characteristic of cholera are: the tendency to occur in explosive outbreaks, provided simultaneous start in different spots, and a propensity to cause true pandemics, progressively affecting many countries on multiple continents over the course of several years. The genus Vibrio includes many different species of which only a few are pathogenic. The classic example of pathogenic genus is V. cholerae. Besides producing cholera toxin, some strains are capable of secreting a pore-forming toxin that induces vacuolization. This review aims to address some molecular aspects of the process of cell damage induced by the vacuolating cytolysin VCC of V. cholerae.


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