Flores-Fragoso G, Avilés-Cobián R, Cardiel-Marmolejo LE

Language: Spanish
References: 14
Page: 215-218
PDF size: 76.82 Kb.

ABSTRACT

The congenital hypothyroidism should be considered like an endocrinology urgency since can have serious sequels as irreversible psychomotor delay. Its frequency in Mexico is of 3.9 cases each 10,000 newborn. Case report: The case of an infant is described that enter to the month of age with classic simptomatology for secondary deficiency of thyroid hormones because a thyroid gland agenesis. The diagnosis you bases on the realization of thyroid gammagram with total absence of thyroid gland which responded favorably to the substitute hormonal therapy. The patient required support ventilation for eight days. Conclusion: The opportune diagnosis and the important of tamiz metabolic contributes to give a specific treatment avoid damage in the intellectual coefficient mainly in patient with thyroid gland agenesis.

REFERENCES

1. DeGroot LJ, Larsen PR, Hennemann G. The thyroid and its diseases. 6th ed. New York: Churchill Livingstone, 1996; 33-112.

2. Toublanc JE. Comparison of epidemiological data on congenital hypothyroidism in Europe with those of other parts in the world. Horm Res 1992; 38: 230-235.

3. Klett M Epidemiology of congenital hypothyroidism. Exp Clin Endocrinol Diabetes 1997; 105 (suppl 4): 19-23.

4. Vulsma T, Gons MH, DeVijlder J. Maternal-fetal transfer of thyroxine in congenital hypothyroidism due to a total organification defect or thyroid dysgenesis. N Engl J Med 1989; 321: 13-16.

5. Lorrey FW, Cunningham GC. Birth prevalence of primary hypothyroidism by sex and ethnicity. Hum Biol 1992; 64: 531-538.

6. Penny R, Hoffman, Barton L. Congenital hypothyroidism in Spanish-surnamed in Southern California: Increased incidence and clustering of ocurrence. Am J Dis Child 1989; 143: 640-641.

7. Tell G, Pellizari L, Esposito G, Pucillo C, Di lauro R et al. Structural defects of a Pax8 mutant that give rise to congenital hypothyroidism. Biochem J 1999; 314: 89-93.

8. La franchi S. Congenital hypothyroidism: etiologies, diagnosis, and management. Thyroid 1999; 9: 735-740.

9. Gould E, Allan MD, McEwen BS. Dendritic spine density of adult hippocampal pyramidal cells is sensitive to thyroid hormone. Brain Res 1990; 525: 327-329.

10. Gravel C, Sasseville R, Hawkes R. Maturation of the corpus callosum. Influence of thyroid hormones on the number and mutation of axons. J Comp Neurol 1990; 291: 147-161.

11. Mallol J, Obregón MJ, Morreale de Escobar G. Analytical artifacts in radioimmunoassay of L-thyroxine in human milk. Clin Chem 1982; 28: 1277-1282.

12. Vulsma T, Gons MH, De Vijlder J. Maternal-fetal transfer of thyroxine in congenital hypothyroidism due to a total organification defect or thyroid dysgenesis. N Engl J Med 1989; 321: 13-16.

13. Chanoine J-P, Alex S, Fang SL et al. Role of transthyretin in the transport of thyroxine from the blood to the coroid plexus, the cerebrospinal fluid and the brain. Endocrinology 1992; 130: 933-938.

14. Vela M, Gamboa S et al. Tamiz neonatal del hipotiroidismo congénito en México. Frecuencia en los últimos 10 años. Act Ped Mex 2000; 21: 99-103.