medigraphic.com

2004, Number 4

<< Back Next >>

Rev Med Hosp Gen Mex 2004; 67 (4)

Clear cell gallbladder carcinoma with alpha fetoprotein production. A case report

Oviedo RMI, Lazos OM

Language: Spanish
References: 17
Page: 211-214
PDF size: 109.71 Kb.


ABSTRACT

Clear cell adenocarcinoma (CCC) of the gallbladder, is an inusual type of carcinoma with predominance of cells with glycogen rich cytoplasm that can be associated with a fetal-protein production. Since its original description in 1986 there has been less than 20 cases described. a fetal-protein production has been widely described in various gastrointestinal and germ cell tumors, highlighting hepatocarcinoma and yolk sack tumors. In the gallbladder it has been identified in papillary, clear cell and poorly differentiated carcinomas. It is important to acknowledge that gallbladder carcinomas can be associated with the production of this marker and thus this entity can be considered within the differential diagnosis of other neoplasms. We present a case of CCC, in a 76 year-old female studied at Hospital General de México.


REFERENCES

  1. Stemberg S. Diagnostic surgical pathology. Vol 1. 3th ed. Philadelphia, PA: Lippincott Williams-Wilkins, 1999; 1629-1661.

  2. Lazcano Ponce E, Miguel JF. Epidemiology and molecular pathology of gallbladder cancer. Ca J Clin 2001; 51: 349-364.

  3. Cotran R. Patología estructural y funcional. 6a ed. México: Mc Graw Hill-Interamericana, 2000; 937-939.

  4. WHO. Tumors of the digestive system. Geneve: World Health Organization, 2002; 208.

  5. Vardaman C, Albores SJ. Clear cell carcinomas of the gallbladder and extrahepatic bile ducts. Am J Surg Pathol 1995; 19: 91-99.

  6. Albores SJ, Molberg K, Henson DE. Unusual malignant epithelial tumors of the gallbladder. Semin Diag Pathol 1996; 13: 326-338.

  7. Albores SJ, Henson DE. Atlas tumor pathology. Tumors of the gallbladder, extrahepatic bile ducts and ampulla de Vater. USA: Armed Forces Institute of Pathology, 1998; 80-83.

  8. Bittinger A, Altekruger I. Clear cell carcinoma of the gallbladder. A histological and immunohistochemical study. PATH Res Pract 1995; 191: 1259-1265.

  9. Sawada H, Watanabe A, Yamada Y et al. Alpha-fetoprotein-producing esophageal adenocarcinoma: Report of a case. Surg Today 1993; 23: 1103-1107.

  10. Aoi A, Nakanishi I, Sakamoto N et al. Alpha feto protein producing gastric carcinoma. Is it hepatoid differentiation? Cancer 1990; 65: 1741-1747.

  11. Matsunon H, Koinshi F, Roswelly AE et al Alpha fetoprotein producing gastric carcinoma with enteroblastic differentiation. Cancer 1994; 73: 534-540.

  12. Kurihara K, Konishi F, Kanazawa K et al. Alpha fetoprotein producing carcinoma of the colorn: Report of a case. Surg Today 1997; 27: 453-456.

  13. Nojima T, Kojima T, Kato T et al. Alpha fetoprotein producing acinar cell carcinoma of the pancreas. Hum Pathol 1992; 23: 828-830.

  14. Ishikura H, Scully R. Hepatoid carcinoma of the ovary. A newly described tumor. Cancer 1987; 60: 2775-2784.

  15. Laurent M, Esteri RM. Gallbladder carcinoma producing alpha fetoprotein. J Clin Gastroenterol 1999; 28: 155-158.

  16. Sugaya Y, Sugaya H. A case of gallbladder carcinoma producing both alpha fetoprotein and carcinoembryonic antigen. Gastroenterol Jpn 1989; 24: 325-331.

  17. Ng WK, Ng WF. Elevated serum alpha fetoprotein in a patient with undifferentiated carcinoma of the gallbladder. J Clin Pathol 1995; 48: 1061-1063.




2020     |     www.medigraphic.com