Charúa GL, Navarrete CT, Osorio HRM, Molina LLA, Avendaño EO

Language: Spanish
References: 15
Page: 15
PDF size: 86.03 Kb.

ABSTRACT

Radiation proctitis is the term used to describe rectal lesions that developed during or after pelvic ionizing radiation to improve the prognosis of patients with pelvic malignancies like cancer of the anus, cervix, prostate gland and rectum. Objective: The goal of this trial is to show the experience with the pharmacological management of radiation proctitis in the Rectal and Colon Unit of The General Hospital in Mexico City, from January 1998 to December 2002. Material and method: Retrospective, longitudinal and descriptive trial was designed including all patients diagnosed with radiation proctitis, submitted to complete clinical history and proctological evaluation. Results: 76 patients were included, 75 females (98.7%) and one male (1.3%), aged between 37 to 76 years with a mean age of 53 years. The most frequent presentation were from 61 to 70 years in 21 cases (27.63%) and among 31 to 40 years in 19 patients (25%). The malignancies that indicated the need for radiation therapy were cancer of the cervix in 75 patients (98.7%) and of the prostate in one (1.3%). Initially all patients were managed with oral mesalacine 2 g divided in three doses. In 18 cases sucralfato was added per rectum three times a day for a total of 3 g per day. Conclusions: Radiation proctitis is definitely more frequent in women. The major cause of radiation is cervix cancer. The vast majority of patients had a good response to pharmacological treatment in the first six months.

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