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ISSN 1561-3011 (Electronic)

2012, Number 4

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Rev Cubana Invest Bioméd 2012; 31 (4)

Association between some cardiovascular risk factors and coronary calcium scoring in symptomatic patients

Olivares AEW, Rodríguez AY, Mendoza RV, Llerena RLR, Cabrera RJO, Tamargo BTO, Milán GE

Language: Spanish
References: 27
Page:
PDF size: 94.21 Kb.


ABSTRACT

Introduction: Knowledge of an individual's overall atherosclerotic burden is extremely important. Its association with cardiovascular risk factors has not been well established.
Objective: Determine the association between some cardiovascular risk factors and coronary calcium scoring.
Methods: A study was conducted of 169 symptomatic patients with suspected ischemic heart disease. The patients consecutively underwent calcium scoring and risk factor identification. Association between the two values was determined by logistic regression modeling.
Results: 106 patients were women and 63 were men; mean age was 59.6 ± 10.8 and 59.5 ± 11.0, respectively. 51.9 % of the women and 34.9 % of the men had a score = 0. Mean effective radiation dose was 0.82 mSv. The variables male patient aged > 55, female patient aged > 65, smoking, diabetes mellitus, age, number of risk factors, VLDL, triglycerides and HDL showed a significant association with some of the calcium score cut-off values established. In the multivariate analysis, age, smoking, triglycerides and HDL as a protective factor, exhibited coefficients significantly different from 0, with age exerting the greatest influence upon the calcium score > 0 and ³ 100 value, and HDL upon the ³ 400 value.
Conclusions: Only some risk factors show an association with coronary calcium score, particularly age and HDL levels as a protective factor.


REFERENCES

  1. Burke AP, Virmani R, Galis Z, Haudenschild CC, Muller JE. Task Force #2-what is the pathologic basis for new atherosclerosis imaging techniques? J Am Coll Cardiol. 2003;41:1874-86.

  2. Arad Y, Goodman KJ, Roth M, Newstein D, Guerci AD. Coronary calcification, coronary disease risk factors, C-reactive protein, and atherosclerotic cardiovascular disease events: the St. Francis Heart Study. J Am Coll Cardiol. 2005;46:158-65.

  3. Church TS, Levine BD, McGuire DK, Lamonte MJ, Fitzgerald SJ, Cheng YJ, et al. Coronary artery calcium score, risk factors, and incident coronary heart disease events. Atherosclerosis. 2007;190:224-31.

  4. Detrano R, Guerci AD, Carr JJ, Bild DE, Burke G, Folsom AR, et al. Coronary calcium as a predictor of coronary events in four racial or ethnic groups. N Engl J Med. 2008;358:1336-45.

  5. Taylor AJ, Cequeira M, Hodgson JM, Mark D, Min J, O'Gara P, et al. ACCF/SCCT/ACR/AHA/ASE/ASNC/SCAI/SCMR 2010 appropriate use criteria for cardiac computed tomography: a report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, the Society of Cardiovascular Computed Tomography, the American College of Radiology, the American Heart Association, the American Society of Echocardiography, the American Society of Nuclear Cardiology, the Society for Cardiovascular Angiography and Interventions, and the Society for Cardiovascular Magnetic Resonance. J Am Coll Cardiol. 2010;56:1864-94.

  6. Ibáñez B, Pinero A, Orejas M, Badimón JJ. Nuevas técnicas de imagen para la cuantificación de la carga aterosclerótica global. Rev Esp Cardiol. 2007;60:299-309.

  7. Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte M, Detrano R. Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol. 1990;15:827-32.

  8. Wayhs R, Zelinger A, Raggi P. High coronary artery calcium scores pose an extremely elevated risk for hard events. J Am Coll Cardiol. 2002;39:225-30.

  9. Mendoza-Rodríguez V, Llerena Rojas LR, Olivares Aquiles EW, Cabrera Rego JO, Armas NB, Hernández Ricardo J. Puntaje de calcio y severidad de la enfermedad coronaria. Rev Cubana Cardiol Cir Cardiovasc. 2010;16:84-98.

  10. Mendoza-Rodríguez V, Llerena Rojas LR, Torres Miranda S, Olivares Aquiles EW, Cabrera Rego JO, Fernández Herrera K, et al. Utilidad del score de calcio en el diagnóstico de enfermedad coronaria obstructiva. Rev Cubana Invest Biomed. 2010;29(4).

  11. Bertomeu V, Cordero A, Quiles J, Mazón P, Aznar J, Bueno H. Control de los factores de riesgo y tratamiento de los pacientes con cardiopatía isquémica: Registo TRECE. Rev Esp Cardiol. 2009;62:807-11.

  12. Marrugat J, Sala J, Elosua R, Ramos R, Baena-Díez JM. Prevención cardiovascular: avances y el largo camino por recorrer. Rev Esp Cardiol. 2010;63(Supl 2):49-54.

  13. Blaha M, Budoff MJ, Shaw LJ, Khosa F, Rumberger JA, Berman D, et al. Absence of coronary artery calcification and all-cause mortality. JACC Cardiovasc Imaging. 2009;2:692-700.

  14. Bild DE, Detrano R, Peterson D, Guerci A, Liu K, Shahar E, et al. Ethnic differences in coronary calcification: the Multi-Ethnic Study of Atherosclerosis (MESA). Circulation. 2005;111:1313-20.

  15. Moselewski F, Christopher JO, Achenbach S, Ferencik M, Massaro J, Nguyen A. Calcium concentration of individual coronary calcified plaques as measured by multidetector row computed tomography. Circulation. 2005;111:3236-41.

  16. Herzog C, Zangos S, Zwerner P, Costello P, Vogl TJ, Schoepf J. CT of coronary artery disease. Thorac Imaging. 2007;22:40-48.

  17. Topol EJ, Nissen SE. Our preoccupation with coronary luminology. The dissociation between clinical and angiographic findings in ischemic heart disease. Circulation. 1995;92:2333-42.

  18. Mintz GS, Painter JA, Pichard AD, Kent KM, Satler LF, Popma JJ, et al. Atherosclerosis in angiographically "normal" coronary artery reference segments: an intravascular ultrasound study with clinical correlations. J Am Coll Cardiol. 1995;25:1479-85.

  19. Kannel WB. Risk factors for atherosclerotic cardiovascular outcomes in different arterial territories. J Cardiovasc Risk. 1994;1:333-39.

  20. Nasir K, Budoff MJ, Wong ND, Scheuner M, Herrington D, Arnett DK, et al. Family history of premature coronary heart disease and coronary artery calcification. Multi-Ethnic Study of Atherosclerosis (MESA). Circulation. 2007;116:619-26.

  21. Rodríguez-Granillo GA, Rosales MA, Madeo M, Diez E, Rodríguez AE. Factores de riesgo y extensión de la enfermedad coronaria evaluada por angiografía coronaria no invasiva. Rev Argent Cardiol. 2008;76:112-117.

  22. Morcillo C, Valderas JM, Roca JM, Oliveró R, Núñez C, Sánchez M, et al. La determinación de calcio coronario con tomografía computarizada en la evaluación del riesgo cardiovascular: un estudio descriptivo. Rev Esp Cardiol. 2007;60:268-75.

  23. Valdés AN, Wolfe ML, Tate HC, Gefter W, Rut A, Rader DJ. Association of traditional risk factors with coronary calcification in persons with a family history of premature coronary heart disease: The study of the inherited risk of coronary atherosclerosis. J Invest Med. 2001;49:353-61.

  24. Folsom AR, Evans GW, Carr JJ, Stillman AE. Association of traditional and nontraditional cardiovascular risk factors with coronary artery calcification. Angiology. 2004;55:613-23.

  25. Donghee K, Su-Yeon C, Eue-Keun C, Jung-Won S, Whal L, Young SK. Distribution of coronary artery calcification in an asymptomatic Korean population: association with risk factors of cardiovascular disease and metabolic syndrome. Korean Circ J. 2008;38:29-35.

  26. Robinson JG, Wang S, Smith BJ, Jacobson TA. Meta-analysis of the relationship between non-high-density lipoprotein cholesterol reduction and coronary heart disease risk. J Am Coll Cardiol. 2009;53:316-22.

  27. Cooney MT, Dudina A, De Bacquer D, Wilhelmsen L, Sans S, Menotti A, et al. HDL cholesterol protects against cardiovascular disease in both genders, at all ages and at all levels of risk. Atherosclerosis. 2009;206:611-16.




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