Narváez-Tovar CA, Garzón-Alvarado DA

Language: Spanish
References: 17
Page: 308-317
PDF size: 185.18 Kb.

ABSTRACT

Long bone elongation is mainly due to proliferation and hypertrophy of the chondrocytes in growth plates. Under the assumption that the behavior of these cells depends on biochemical and mechanical factors, a presentation is made of a computational finite element model simulating the behavior of the human distal femoral growth plate. A two-dimensional domain is used to identify the regions of metaphyseal and epiphyseal trabecular bone covering the growth plate and the inert and columnar cartilage regions. Model validation was based on the histology corresponding to the distal femoral growth plate of a two-year old boy. The results obtained show that the model simulates the growth and behavior of the metaphyseal plate as regulated by its cellular activity and mechanical loads.

REFERENCES

1. Villemure I, Stokes IA. Growth plate mechanics and mechanobiology. A survey of present understanding. Journal of Biomechanics. 2009;42:1793-1803.

2. Kember, NF, Sissons, HA. Quantitative histology of the human growth plate. The journal of bone and joint surgery. 1976;58-B(4):426-35.

3. Kindblom JM, Nilsson O, Hurme T, Ohlsson C, Savendahl J. Expression and localization of Indian Hedgehog (Ihh) and parathyroid hormone related protein (PTHrP) in the human growth plate during pubertal development. Journal of Endocrinology. 2002;174:R1-R6.

4. Delpech JM. De L'Orthomorphie. 2 vol. Paris: Gabon; 1828.

5. Stokes IA, Mente PL, Iatridis JC, Farnum CE, Aronsson DD. Enlargement of growth plate chondrocytes modulated by sustained mechanical loading. Journal of Bone and Joint Surgery. 2002;84-A:1842-48.

6. Stokes IA, Clark KC, Farnum CE, Aronsson DD. Alterations in the growth plate associated with growth modulation by sustained compression or distraction. Bone. 2007;41(2):197-205.

7. Stokes A, Aronsson DD, Dimock AN, Cortright V, Beck S. Endochondral growth in growth plates of three species at two anatomical locations modulated by mechanical compression and tension. J. Orthop. Res. 2006. 24 (6): 1327-1334.

8. Brouwers JE, Van Donkelaar CC, Sengers BG, Huiskes R. Can the growth factors PTHrP, Ihh and VEGF, together regulate the development of a long bone? J Biomech. 2006;39(15):2774-82.

9. Garzón-Alvarado DA, García-Aznar JM, Doblaré M. A reaction-diffusion model for long bones growth. Biomech Model Mechanobiol. 2009. 8(5):381-95.

10. Carter, DR, Wong M. Mechanical stresses and endochondral ossification in the chondroepiphysis. J Orthop Res. 1988;6(1):148-54.

11. Lin H, Aubin C, Parent S, Villemure I. Mechanobiological bone Growth: Comparative analysis of two biomechanical modeling approaches. Medical and Biological Engineering and Computing. 2009. 47(4):357-66.

12. Garzón-Alvarado, DA, Narváez-Tovar CA, Silva, O. Um modelo matemático de la placa de crecimiento. Revista Cubana de Investigaciones Biomédicas 2011;30(1): 42-63.

13. Cancel, Grimard G, Thuillard-Crisinel D, Moldovan F, Villemure I. Effects of in vivo static compressive loading on aggrecan and type II and X collagens in the rat growth plate extracellular matrix. Bone. 2009;44(2):306-15.

14. Villemure, Chung MA, Seck CS, Kimm MH, Matyas JR, Duncan NA. Static compressive loading reduces the mRNA expression of type II and X collagen in rat growth-plate chondrocytes during postnatal growth. Connect. Tissue Res. 2005;46 (4-5):211-19.

15. Piszczatowski, S. Material aspects of growth plate modelling using Carter's and Stokes's approaches. Acta of Bioengineering and Biomechanics. 2011. 13(3): 3-14.

16. Sergerie K, Lacoursiere MO, Levesque M, Villemure I. Mechanical properties of the porcine growth plate and its three zones from unconfined compression tests. J. Biomech. 2009;42(4):510-16.

17. Sylvestre, P, Villemure, I, Aubin, C. Finite element modeling of the growth plate in a detailed spine model.Med Bio Eng Comput. 2007;45:977-88.