2007, Number 2
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Rev Educ Bioquimica 2007; 26 (2)
Participación de la subunidad Gαde proteínas G heterotriméricas en los procesos de virulencia y patogenicidad de los hongos
Sánchez PE, Alcántara HR, Torres MME
Language: Spanish
References: 15
Page: 58-65
PDF size: 159.5 Kb.
ABSTRACT
Heterotrimeric G proteins function as signal
transduction molecules between membrane receptors
and effectors. In fungi, they play a crucial role in mating
and pathogenesis. Furthermore G proteins participate
in some development and morphogenesis processes,
which determine their virulence in plant and animals.
In this review some findings that shed light on
identifying the genes and functions of G proteins within
signalling pathways participating on virulence and
pathogenesis of some fungi are described.
REFERENCES
Wettschureck N, Offermanns S (2005) Mammalian G proteins and their cell type specific functions. Physiol Rev 85:1159-1204.
Madhani HD, Fink GR (1998) The control of filamentous differentiation and virulence in fungi. Trends Cell Biol 8:348-353.
Dohlman HG (2002) G proteins and pheromone signalling. Annu Rev Physiol 64:129-152.
Rangel Serrano A (1998) Función y propiedades bioquímicas de las proteínas G. BEB 18: 53-59.
Dietzel C, Kurjan J (1987) The yeast SCG1 gene: a G alpha-like protein implicated in the a- and alpha-factor response pathway. Cell 50:1001-1010.
Kübler E, Mosch HU, Rupp S, Lisanti MP (1997) Gpa2p a Gprotein alpha-subunit, regulates growth and pseudohyphal development in Saccharomyces cerevisiae via a cAMPdependent mechanism. J Biol Chem 272: 20321-20323.
Maidan MM, De Rop L, Serneels J, Exler S, Rupp S, Tourna H, Thevelein JM, Van Dijck P (2005) The G proteincoupled receptor Gpr1 and the Gα protein Gpa2 act through the cAMP-Protein Kinase A pathway to induce morphogenesis in Candida albicans. Mol Biol Cell 16: 1971-1986.
López-Martínez R, Méndez-Tovar LJ, Hernández- Hernández F, Castañón-Olivares R (2004) Micología Médica. Procedimientos para el diagnóstico de laboratorio. Editorial Trillas, Mexico, D.F. pp.192.
Sánchez-Martinez C, Pérez-Martin J (2002) Gpa2, a Gprotein a subunit required for hyphal development in Candida albicans. Eukaryotic Cell 1, 865-874.
Lengeler KB, Davidson RC, D´Souza C, Harashima T, Shen WC, Wang P, Pan X, Waugh M, Heitman J (2000) Signal Transduction Cascades Regulating Fungal Development and Virulence. Microbiol Mol Biol Rev. 64:746-785.
Noverr MC, Williamson PR, Fajardo RS, Huffnagle GB (2004) CNLAC1 is required for extrapulmonary dissemination of Cryptococcus neoformans but not pulmonary persistence. Infect Immun 72:1693-1699.
Alspaugh JA, Perfect JR, Heitman J (1997) Cryptococcus neoformans mating and virulence are regulated by the G-protein alpha subunit GPA1 and cAMP. Genes Dev. 1:3206-3217.
Bahn YS, Hicks JK, Giles SS, Cox GM, Heitman J (2004) Adenylyl cyclase- associated protein Aca1 regulates virulence and differentiation of Cryptococcus neoformans via the cyclic AMP-protein kinase A cascade. Eucaryot Cell 3:1476-1491.
Regenfelder E, Spelling T, Hartmann A, Lauenstein S, Bölker M, Kahmann R (1997) G proteins in Ustilago maydis: transmission of multiple signals? EMBO J 16:1934-1942.
Liu S, Dean RA (1997) G protein alpha subunit genes control growth, development and pathogenicity of Magnaporthe grisea. Mol Plant Microbe Interact 10:1075-1086.