2007, Número 2
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Rev Educ Bioquimica 2007; 26 (2)
Mecanismos moleculares que intervienen en el transporte de la glucosa
Castrejón V, Carbó R, Martínez M
Idioma: Español
Referencias bibliográficas: 21
Paginas: 49-57
Archivo PDF: 257.87 Kb.
RESUMEN
El transporte de la glucosa a través de la membrana
plasmática de las células de mamífero representa uno
de los eventos más importantes del transporte de
nutrientes ya que este azúcar tiene un papel central en
el metabolismo y en la homeostasis celular. El ingreso
de la glucosa a las células se realiza mediante dos tipos
de proteínas acarreadoras: los transportadores de glucosa
asociados a sodio (SGLT) y los sistemas facilitadores
del transporte de glucosa (GLUT). Esta revisión presenta
las principales características moleculares, bioquímicas y
funcionales de cada transportador.
REFERENCIAS (EN ESTE ARTÍCULO)
Czech MP, Corvera S (1999) Signaling mechanisms that regulate glucose transport. J Biol Chem 274(4):1865-1878.
Scheepers A, Joost H G, Schurmann A (2004) The glucose transporter families SGLT and GLUT: molecular basis of normal and aberrant function. JPEN J Parenter Enteral Nutr 28:364 - 371.
Wright EM. (1998) Glucose galactose malabsorption. Am J Physiol 275: G879 - 882.
Brown GK (2000) Glucose transporters: structure, function and consequences of deficiency. J Inherit Metab Dis 23:237 - 246.
Diez-Sampedro A, Hirayama BA, Oswald C, Gorboulev V, Baumgarten K, Volk C, Wright EM, Koepsell H (2003) A glucose sensor hiding in a family of transporters. Proc Natl Acad Sci U S A 100:11753 -11758.
Barrett MP, Walmsley AR, Gould G W (1999) Structure and function of facilitative sugar transporters. Curr Opin Cell Biol 11:496 - 502.
Klepper J, Voit T (2002) Facilitated glucose transporter protein type 1 (GLUT 1) deficiency syndrome: impaired glucose transport into brain. Eur J Pediatr 161:295 - 304.
Li SR, Baroni MG, Oelbaum RS, Stock J, Galton DJ (1988) Association of genetic variant of the glucose transporter with non-insulin-dependent diabetes mellitus. Lancet II: 368-370.
Santer R, Steinmann B, Schaub J (2002) Fanconi-Bickel syndrome-a congenital defect of facilitative glucose transport. Curr Mol Med 2:213 - 227.
Lesage J, Hahn D, Leonhardt M, Blondeau B, Breant B, Dupouy JP. (2002) Maternal undernutrition during late gestation-induced intrauterine growth restriction in the rat is associated with impaired placental GLUT 3 expression, but does not correlate with endogenous corticosterone levels. J Endocrinol 174:37 - 43.
Mastick CC, Aebersold R, Lienhard GE (1994) Characterization of a major protein in GLUT 4 vesicles. Concentration in the vesicles and insulin-stimulated translocation to the plasma membrane. J Biol Chem 269:6089 - 6092.
Matthaei S, Stumvoll M, Kellerer M, Häring HU (2000) Pathophysiology and pharmacological treatment of insulin resistance. Endocrine Rev 21:585-618.
Wu X, Freeze HH (2002) GLUT 14, a duplicon of GLUT 3, is specifically expressed in testis as alternative splice forms. Genomics 80(6):553 - 557.
Godoy A, Ulloa V, Rodriguez F, Reinicke K, Yanez AJ, Garcia M de L, Medina RA, Carrasco M, Barberis S, Castro T, Martinez F, Koch X, Vera JC, Poblete MT, Figueroa CD, Peruzzo B, Perez F, Nualart F (2006) Differential subcellular distribution of glucose transporters GLUT 1-6 and GLUT 9 in human cancer: Ultrastructural localization of GLUT 1 and GLUT 5 in breast tumor tissues. J Cell Physiol 207:614 - 627.
Li Q, Manolescu A, Ritzel M, Yao S, Slugoski M, Young JD, Chen XZ, Cheeseman CI (2004) Cloning and functional characterization of the human GLUT 7 isoform SLC2A7 from the small intestine. Am J Physiol Gastrointest Liver Physiol 287:G236 -G242.
Carayannopoulos MO, Schlein A, Wyman A, Chi M, Keembiyehetty C, Moley KH (2004) GLUT 9 is differentially expressed and targeted in the preimplantation embryo. Endocrinol 145:1435 - 1443.
Doege H, Bocianski A, Scheepers A, Axer H, Eckel J, Joost HG, Schurmann A (2001) Characterization of human glucose transporter (GLUT) 11 (encoded by SLC2A11), a novel sugar-transport facilitator specifically expressed in heart and skeletal muscle. Biochem J 359: 443 -449.
Ibberson M, Uldry M, Thorens B (2000) GLUTX1, a novel mammalian glucose transporter expressed in the central nervous system and insulin-sensitive tissues. J Biol Chem 275:4607 - 4612.
McVie-Wylie AJ, Lamson DR, Chen YT (2001) Molecular cloning of a novel member of the GLUT family of transporters, SLC2a10 (GLUT 10), localized on chromosome 20q13.1: a candidate gene for NIDDM susceptibility. Genomics 72:113 -117.
Rogers S, Macheda ML, Docherty SE, Carty MD, Henderson MA, Soeller WC, Gibbs EM, James DE, Best JD (2002) Identification of a novel glucose transporterlike protein-GLUT-12. Am J Physiol Endocrinol Metab 282:E733 - E738.
Uldry M, Ibberson M, Horisberger JD, Chatton JY, Riederer BM, Thorens B (2001) Identification of a mammalian H(+)-myo-inositol symporter expressed predominantly in the brain. EMBO J 20:4467 - 4477.