2007, Number 2
<< Back Next >>
Rev Educ Bioquimica 2007; 26 (2)
Mecanismos moleculares que intervienen en el transporte de la glucosa
Castrejón V, Carbó R, Martínez M
Language: Spanish
References: 21
Page: 49-57
PDF size: 257.87 Kb.
ABSTRACT
The transport of glucose across the plasma membrane
of mammalian cells represents one of the most
important nutrient transport events since this sugar plays
a central role in cellular homeostasis and metabolism.
Glucose enters the cells through two types of carrier
proteins, the sodium - coupled glucose transporters
(SGLT) and glucose transporter facilitators or carriers
(GLUT). This review shows the principal molecular,
biochemical and functional properties of each
transporter.
REFERENCES
Czech MP, Corvera S (1999) Signaling mechanisms that regulate glucose transport. J Biol Chem 274(4):1865-1878.
Scheepers A, Joost H G, Schurmann A (2004) The glucose transporter families SGLT and GLUT: molecular basis of normal and aberrant function. JPEN J Parenter Enteral Nutr 28:364 - 371.
Wright EM. (1998) Glucose galactose malabsorption. Am J Physiol 275: G879 - 882.
Brown GK (2000) Glucose transporters: structure, function and consequences of deficiency. J Inherit Metab Dis 23:237 - 246.
Diez-Sampedro A, Hirayama BA, Oswald C, Gorboulev V, Baumgarten K, Volk C, Wright EM, Koepsell H (2003) A glucose sensor hiding in a family of transporters. Proc Natl Acad Sci U S A 100:11753 -11758.
Barrett MP, Walmsley AR, Gould G W (1999) Structure and function of facilitative sugar transporters. Curr Opin Cell Biol 11:496 - 502.
Klepper J, Voit T (2002) Facilitated glucose transporter protein type 1 (GLUT 1) deficiency syndrome: impaired glucose transport into brain. Eur J Pediatr 161:295 - 304.
Li SR, Baroni MG, Oelbaum RS, Stock J, Galton DJ (1988) Association of genetic variant of the glucose transporter with non-insulin-dependent diabetes mellitus. Lancet II: 368-370.
Santer R, Steinmann B, Schaub J (2002) Fanconi-Bickel syndrome-a congenital defect of facilitative glucose transport. Curr Mol Med 2:213 - 227.
Lesage J, Hahn D, Leonhardt M, Blondeau B, Breant B, Dupouy JP. (2002) Maternal undernutrition during late gestation-induced intrauterine growth restriction in the rat is associated with impaired placental GLUT 3 expression, but does not correlate with endogenous corticosterone levels. J Endocrinol 174:37 - 43.
Mastick CC, Aebersold R, Lienhard GE (1994) Characterization of a major protein in GLUT 4 vesicles. Concentration in the vesicles and insulin-stimulated translocation to the plasma membrane. J Biol Chem 269:6089 - 6092.
Matthaei S, Stumvoll M, Kellerer M, Häring HU (2000) Pathophysiology and pharmacological treatment of insulin resistance. Endocrine Rev 21:585-618.
Wu X, Freeze HH (2002) GLUT 14, a duplicon of GLUT 3, is specifically expressed in testis as alternative splice forms. Genomics 80(6):553 - 557.
Godoy A, Ulloa V, Rodriguez F, Reinicke K, Yanez AJ, Garcia M de L, Medina RA, Carrasco M, Barberis S, Castro T, Martinez F, Koch X, Vera JC, Poblete MT, Figueroa CD, Peruzzo B, Perez F, Nualart F (2006) Differential subcellular distribution of glucose transporters GLUT 1-6 and GLUT 9 in human cancer: Ultrastructural localization of GLUT 1 and GLUT 5 in breast tumor tissues. J Cell Physiol 207:614 - 627.
Li Q, Manolescu A, Ritzel M, Yao S, Slugoski M, Young JD, Chen XZ, Cheeseman CI (2004) Cloning and functional characterization of the human GLUT 7 isoform SLC2A7 from the small intestine. Am J Physiol Gastrointest Liver Physiol 287:G236 -G242.
Carayannopoulos MO, Schlein A, Wyman A, Chi M, Keembiyehetty C, Moley KH (2004) GLUT 9 is differentially expressed and targeted in the preimplantation embryo. Endocrinol 145:1435 - 1443.
Doege H, Bocianski A, Scheepers A, Axer H, Eckel J, Joost HG, Schurmann A (2001) Characterization of human glucose transporter (GLUT) 11 (encoded by SLC2A11), a novel sugar-transport facilitator specifically expressed in heart and skeletal muscle. Biochem J 359: 443 -449.
Ibberson M, Uldry M, Thorens B (2000) GLUTX1, a novel mammalian glucose transporter expressed in the central nervous system and insulin-sensitive tissues. J Biol Chem 275:4607 - 4612.
McVie-Wylie AJ, Lamson DR, Chen YT (2001) Molecular cloning of a novel member of the GLUT family of transporters, SLC2a10 (GLUT 10), localized on chromosome 20q13.1: a candidate gene for NIDDM susceptibility. Genomics 72:113 -117.
Rogers S, Macheda ML, Docherty SE, Carty MD, Henderson MA, Soeller WC, Gibbs EM, James DE, Best JD (2002) Identification of a novel glucose transporterlike protein-GLUT-12. Am J Physiol Endocrinol Metab 282:E733 - E738.
Uldry M, Ibberson M, Horisberger JD, Chatton JY, Riederer BM, Thorens B (2001) Identification of a mammalian H(+)-myo-inositol symporter expressed predominantly in the brain. EMBO J 20:4467 - 4477.