Ferguson D, ánchez E, Rojo J

Language: Spanish
References: 15
Page: 136-141
PDF size: 142.74 Kb.

ABSTRACT

The diagnosis of sickle cell disease is based on identification of hemoglobin S (HbS). In the homocigote patient, the clinic manifestations are given because of sickling and/or hemolysis. In the sickle trait (hemoglobin AS), there are in general no symptoms. It is necessary in both cases, to make diagnostic laboratory studies. In the first case, the sickle cells and other erythrocyte alterations may be seen in peripheral blood smears. In patients and carriers the hemoglobin S is diagnosticated by sickle-cell induction and by solubility tests, but hemoglobin electrophoresis must be done definitively for the diagnosis. In this study we made hemoglobin electrophoresis in 777 blood samples from students and found that 7.7% of them were Hb AS carriers.

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