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Colegio de Medicina Interna de México.

2012, Number 5

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Med Int Mex 2012; 28 (5)

Analgesic Effect of B Vitamins, 50 Years after the First Fixed Combination of Thiamine, Pyridoxine and Cyanocobalamin

Torres A, Gutiérrez R

Language: Spanish
References: 33
Page: 473-482
PDF size: 258.59 Kb.


ABSTRACT

Vitamins that belong to the so called B omplex, specifically thiamine or vitamin B1, pyridoxine or vitamin B6, and cobalamine or vitamin B12, have been utilized either alone or combined as food supplements in cases of serum deficiencies. Nevertheless, vitamins recognized also as neurotrophic, have pharmacological effects as well. One of these biological effects is analgesia, effect little known, but proven both experimentally, and clinically. B vitamins deficiency associated neuropathies pathophysiological bases are reviewed, specifically related to diabetes mellitus and chronic alcoholism, as well as clinical trials that have shown both their efficacy and tolerability.


REFERENCES

  1. Wang ZB, Gan Q, Rupert RL, et al. Thiamine, pyridoxine, cyanocobalamin and their combination inhibit thermal, but not mechanical hyperalgesia in rats with primary sensory neuron injury. Pain 2005;114:266-277.

  2. Reyes-García G, Caram-Salas NL, Medina-Santillán R, et al. Oral administration of B vitamins increases the antiallodynic effect of gabapentin in the rat. Proc West Pharmacol Soc 2004;47:76-79.

  3. Nilsson-Ehle H. Age-related changes in cobalamin (vitamin B12) Handling implications for therapy. Drugs Aging 1998;12(4):277-292.

  4. Song XS, Huang ZJ, Song XJ. Thiamine suppresses thermal hyperalgesia, inhibits hyperexcitability, and lessens alterations of sodium currents in injured, dorsal root ganglion neurons in rats. Anesthesiology 2009;110(2):387-400.

  5. Jurna I. Analgesic and analgesia-potentiating action of B vitamins. Schmerz 1998;12(2):136-141.

  6. Vetter G, Brüggenmann G, Lettko M, et al. Shortening diclofenac therapy by B vitamins. Results of a randomized doubleblind study, diclofenac 50 mg versus diclofenac 50 mg plus B vitamins, in painful spinal diseases with degenerative changes. Z Rheumatol 1998;47(5):351-362.

  7. Chopra K, Tiwari V. Alcoholic neuropathy: Possible mechanisms and future treatment possibilities. Br J Clin Pharmacol 2012;73(3):348-362.

  8. Bâ A. Metabolic and structural role of thiamine in nervous tissues. Cell Mol Neurobiol 2008; 2008:923-31.

  9. Kretschmar C, Kaumeier S, Haase W. Medicamentous therapy of alcoholic polyneuropathy. Fortschr Med 1996;114(32):439-443.

  10. Woelk H, Lehrl S, Bitsch R, y col. Benfotiamine in treatment of alcoholic polyneuropathy: An 8-week randomized controlled study (BAP I Study). Alcohol Alcohol 1998;33(6):631-638.

  11. Anisimova EI, Danilov AB. Benfotiamine efficacy in alcoholic polyneuropathy therapy. Zh Nevrol Psikhiatr Im S S Korsakova 2001;101(12):32-6.

  12. Peters TJ, Kotowicz J, Nyka W, et al. Treatment of alcoholic polyneuropathy with vitamin B complex: A randomised controlled trial. Alcohol Alcohol 2006;41(6):636-642.

  13. Avena R, Arora S, Carmody BJ, et al. Thiamine (vitamin B1) protects against glucose- and insulin-mediated proliferation of human infragenicular arterial smooth muscle cells Ann Vasc Surg 2000;14(1):37-43.

  14. Edwards JL, Vincent AM, Cheng HT, et al. Diabetic neuropathy: Mechanisms to management. Pharmacol Ther 2008;120:1-34.

  15. Jolivalt CG, Mizisin LM, Nelson A, et al. B vitamins alleviate indices of neuropathic pain in diabetic rats. Eur J Pharmacol 2009;612(1):41-47.

  16. Devathasan G, Teo WL, Mylvaganam A. Methylcobalamin (CH3-B12; methylcobal) in chronic diabetic neuropathy: A double blind clinical and electrophysiological study. Clin Trials J 1986;23(2):130-140.

  17. Yaqub BA, Siddique A, Sulimani R. Effects of methylcobalamin on diabetic neuropathy. Clin Neurol Neurosurg 1992;94(2):105-111.

  18. Shindo H, Tawata M, Inoue M, et al. The effect of -prostaglandin El-&D on determined with the SMV-5 vibrometer in neuropathy. Diabetes Res Clin Pract 1994;24(3):173-180.

  19. Stracke H, Lindemann A, Federlin K. A benfotiamine-vitamin B combination in treatment of diabetic neuropathy. Exp Clin Endocrinol Diabetes 1996;104(4):311-316.

  20. Abbas ZG, Swai AB. Evaluation of the efficacy of thiamine and pyridoxine in the treatment of symptomatic diabetic peripheral neuropathy. East Afr Med J 1997;74(12):803-808.

  21. Simeonov S, Pavlova M, Mitkov M, et al. Therapeutic efficacy of “Milgamma” in patients with painful diabetic neuropathy. Folia Med (Plovdiv)1997;39(4):5-10.

  22. Sadekov RA, Danilov AB, Veĭn AM. Diabetic polyneuropathy treatment by milgamma-100 preparation. Zh Nevrol Psikhiatr S S Korsakova 1998;98(9):30-32.

  23. Winkler G, Pál B, Nagybéganyi E, et al. Effectiveness of different benfotiamine dosage regimens in the treatment of painful diabetic neuropathy. Arzneimittelforschung 1999;49(3):220-224.

  24. Li G. Effect of mecobalamin on diabetic neuropathies. Zhonghua Nei Ke Za Zhi 1999;38(1):14-7.

  25. Kuwabara S, Nakazawa R, Azuma N, et al. Intravenous methylcobalamin treatment for uremic and diabetic neuropathy in chronic hemodialysis patients. Internal Medicine 1999;38(6):472-5. Internal Medicine 1999;38(6):472-475.

  26. Haupt E, Ledermann H & Köpcke W. Benfotiamine in the treatment of diabetic polyneuropathy- A three week randomized, controlled pilot study (BEDIP Study). Int J Clin Pharm Ther 2005;43(2):71-77.

  27. Sun Y, Lai MS, Lu CJ. Effectiveness of vitamin B12 on diabetic neuropathy: Systematic review of clinical controlled trials. Acta Neurol Taiwan 2005;14(2):48-54.

  28. Stracke H, Gaus W, Achenbach U, y col. Benfotiamine in diabetic polyneuropathy (BENDIP): Results of a randomised, double blind, placebo controlled clinical study. Exp Clin Endocrinol Diabetes 2008;116(10):600-605.

  29. Nikolić A, Kacar A, Lavrnić D, y col. The effect of benfotiamine in the therapy of diabetic polyneuropathy. Srp Arh Celok Lek 2009;137(11-12):594-600.

  30. Talaei A, Siavash m, Majidi H, y col. Vitamin B12 may be more effective than nortriptyline in improving painful diabetic neuropathy. Int J Food Sci Nutr 2009;60(Suppl 5):71-76.

  31. Solomon LR. Diabetes as a cause of clinically significant functional cobalamin deficiency. Diabetes Care 2011;34(5):1077-1080.

  32. Callaghan BC, Little AA, Feldman EL, et al. Enhanced glucose control for preventing and treating diabetic neuropathy (Review). Cochrane Database of Systematic Reviews 2012, Issue 6. Art. No.: CD007543. DOI: 10.1002/14651858.CD007543.pub2.

  33. Hammes HP, Du X, Eldestein D, Taguchi T, et al. Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy. Nature Med 2003;9(3):294-299.




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