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2009, Number 4

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Rev Educ Bioquimica 2009; 28 (4)

Efectos del ejercicio sobre los mecanismos celulares para la captación de glucosa en el músculo esquelético

Ramos-Jiménez A, Hernández-Torres RP, Wall-Medrano A, Torres-Durán PV, Juárez-Oropeza MA

Language: Spanish
References: 36
Page: 115-124
PDF size: 347.76 Kb.


ABSTRACT

GLUT-4 is the major glucose transporter-isoform, expressed in skeletal muscle, and it is translocated from the intracellular location to the plasma membrane and T tubules. Translocation of GLUT-4 is the principal mechanism through both, insulin and exercise, increase skeletal muscle glucose-transport. GLUT-4 settles intracellular in small-vesicle pool and by the activation of diverse intracellular mechanisms (the majority unknown), these vesicles are translocated to the cytoplasmic membrane, and by exocytosis the glucose transporters (GLUT-4) are integrated into cellular membrane, allowing the glucose uptake. In this work, are described diverse mechanisms that permit the GLUT-4 to increase its intracellular concentrations, translocating to the sarcoplasma, and settle in the membrane and to promote the glucose uptake. In addition, it will be mentioned the mechanisms activated by the exercise in these processes.


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