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2009, Number 2

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Rev Educ Bioquimica 2009; 28 (2)

El factor inducido por lahipoxia-1 (HIF-1) y la glucólisis en las células Tumorales

Marín-Hernández A

Language: Spanish
References: 37
Page: 42-51
PDF size: 294.92 Kb.


ABSTRACT

The hypoxia-inducible factor 1 (HIF-1) is an important key mediator during low-oxygen cellular adaptation. Several genes involved in angiogenesis, erythropoiesis, energy metabolism and cell survival are up-regulated by HIF-1. In tumour cells, HIF-1 overexpression and activation is associated with malignancy, development and angiogenesis; whereas HIF-1 low expression has been determined in normal tissues and benign tumors. At metabolic level, HIF- 1-activation stimulates transporters (GLUT1, GLUT3) and glycolytic enzymes (HKI, HKII, PFK-L,ALD-A, ALD-C, PGK1, ENO-α, PYK-M2, LDH-A, PFKFB- 3) transcription. In consequence, a significant increment in the glycolytic flux (lactate ,ATP, and H+) and glycolytic intermediates levels are attained. An additional role of some of these HIF-induced isoforms as activators of survival, histones transcriptional activation (LDH-A), apoptotic inhibition (HKI y HKII) and cellular migration (ENO-α) pathways is discussed.


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