Benítez-Guzmán A, Torres-Márquez ME

Language: Spanish
References: 15
Page: 74-81
PDF size: 409.22 Kb.

ABSTRACT

The inflammatory response involves cytokines generation, in which NFkB transcription factor is activated by either MAPK or IKKβ kinase pathways;those pathways are also under the regulation of ubiquitination/deubiquitination process. To establish an infection, bacteria have developed interference mechanisms to host´s ubiquitination and MAPK pathways. Ubiquitination is interfered when bacterial toxins mimic either host E3 ligases or deubiquitination reactions in order to selectively avoid protein degradation. Bacterial toxins also interfere with MAPK pathway by dephosphrorylating or modifying its components to avoid their activation. In this review, we focus on bacterial toxins with ubiquitination/deubiquitinacion action and its influence on the inflammation response.

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