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2010, Number 2

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Rev Educ Bioquimica 2010; 29 (2)

El marcapaso del corazón puede ser modulado por la acetilcolina mediante una vía delimitada a la membrana

Farías JM, Mascher D, Paredes-Carbajal MC, Torres-Durán PV, Juárez-Oropeza MA

Language: Spanish
References: 29
Page: 29-38
PDF size: 306.55 Kb.


ABSTRACT

Acetylcholine is a neurotransmitter released by the vagus nerve that binds to the muscarinic M2 receptor of heart pacemaker cells. Ligand-receptor binding releases a beta-gamma dimmer from the G protein. This dimmer remains anchored to the inner surface of the plasma membrane, exerting a fast, direct, membrane delimited action that does not require phosphorylation of K+ channels. These channels, initially called K (Ach), produce a slow depolarization of the pacemaker cell, decreasing the heart rate. In addition, acetylcholine initiates and maintains slow modulation mechanisms that require soluble intracellular messengers, activation of kinases and phosphorylation. We also review the adrenergic action, complementary and antagonistic to cholinergic response.


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