2010, Número 2
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Rev Educ Bioquimica 2010; 29 (2)
El marcapaso del corazón puede ser modulado por la acetilcolina mediante una vía delimitada a la membrana
Farías JM, Mascher D, Paredes-Carbajal MC, Torres-Durán PV, Juárez-Oropeza MA
Idioma: Español
Referencias bibliográficas: 29
Paginas: 29-38
Archivo PDF: 306.55 Kb.
RESUMEN
La acetilcolina es un neurotransmisor liberado por el nervio vago que se une al
receptor muscarínico M
2 en las células marcapaso del corazón. Esta unión ligandoreceptor
activa una proteína G de la cual sale el dímero beta-gamma. Este dímero
se mantiene anclado a la cara interna de la membrana plasmática, ejerciendo una
acción rápida, directa, delimitada a la membrana y que no requiere fosforilación sobre
los canales de K+. Estos canales, inicialmente llamados K(Ach), hacen que sea más
lenta la despolarización de la célula marcapaso y disminuya la frecuencia cardiaca.
Además, la acetilcolina puede iniciar y mantener mecanismos de modulación lentos,
con mensajeros intracelulares solubles, activación de cinasas y fosforilación. Se revisó
también la acción adrenérgica complementaria y antagónica a la respuesta colinérgica.
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