Ortega-Gutiérrez C, Luna-Ortiz K, Villavicencio-Valencia V, Herrera-Gómez A, Téllez-Palacios D, Contreras-Buendía M

Language: Spanish
References: 11
Page: 448-450
PDF size: 85.87 Kb.

ABSTRACT

Background: hypothyroidism following total laryngectomy or radiotherapy treatment for laryngeal cancer is not a rare event, especially in advanced stages. There are no reports on the incidence of hypothyroidism in patients who received chemotherapy and radiotherapy. The objective of this study is to determine the incidence of thyroid dysfunction in a group of patients with laryngeal cancer who underwent surgery as sole treatment, total laryngectomy or radiotherapy alone, and patients with combined treatment: surgery plus radiotherapy, concomitant chemoradiation therapy and chemoradiation therapy plus salvage surgery.
Methods: a prospective study of patients diagnosed with laryngeal cancer whose serum TSH and T4 levels were evaluated in a serial fashion.
Results: 70 patients with laryngeal cancer were studied; the average age at diagnosis was 70.2 years. Male patients were more affected, with a men-women ratio of 3.6:1. Glottic localization was the most frequent (44%). 64% of tumors were locally advanced carcinomas and 51% received multimodal treatment. 45 patients (63%) were diagnosed with hypothyroidism; 49% of the patients with subclinical hypothyroidism, and 51% with clinical hypothyroidism.
Conclusions: hypothyroidism is a complication following treatment for laryngeal cancer. It is recommended to evaluate the thyroid function periodically for timely detection.

REFERENCES

1. Bahadur S, Iyer S, Kacker SK. The thyroid gland in the management of carcinoma of the larynx and laryngopharynx. J Laryngol Otol 1985;99(12):1251-1253.

2. Nishiyama K, Tanaka E, Tarui Y, Miyauchi K, Okagawa K. A prospective analysis of subacute thyroid dysfunction after neck irradiation. Int J Radiat Oncol Biol Phys 1996;34(2):439-444.

3. Shafer RB, Nuttall FQ, Pollak K, Kuisk H. Thyroid function after radiation and surgery for head and neck cancer. Arch Intern Med 1975;135(6):843-846.

4. Romero A, Esteban F, Delgado M, Solanellas J, Soldado L, Fernández I, et al. Hypothyroidism in patients treated for laryngeal cancer: preliminary results. Acta Otorrinolaringol Esp 1999;50(3):205-210.

5. Ho ACW, Ho WK, Lam PKY, Yuen APW, Wei WI. Thyroid dysfunction in laryngectomees-10 years after treatment. Head Neck 2008;30(3):336-340.

6. Tell R, Sjödin H, Lundell G, Lewin F, Lewensohn R. Hypothyroidism after external radiotherapy for head and neck cancer. Int J Radiat Oncol Biol Phys 1997;39(2):303-308.

7. Thorp MA, Levitt NS, Mortimore S, Isaacs S. Parathyroid and thyroid function five years after treatment of laryngeal and hypopharyngeal carcinoma. Clin Otolaryngol Allied Sci 1999;24(2):104-108.

8. Miller MC, Agrawal A. Hypothyroidism in postradiation head and neck cancer patients: incidence, complications, and management. Curr Opin Otolaryngol Head Neck Surg 2009;17(2):111-115.

9. Alkan S, Baylancicek S, Çiftçic M, Sozen E, Dadaş B. Thyroid dysfunction after combined therapy for laryngeal cancer: A prospective study. Otolaryngol Head Neck Surg 2008;139(6):787-791.

10. Lo GAM, de Bree R, Kuik DJ, Lips PT, Mary B, Von Blomberg, et al. The prevalence of hypothyroidism after treatment for laryngeal and hypopharyngeal carcinomas: are autoantibodies of influence? Acta Otolaryngol 2007;127(3):312-317.

11. Sinard RJ, Tobin EJ, Mazzaferri EL, Hodgson SE, Young DC, Kunz AL, et al. Hypothyroidism after treatment for nonthyroid head and neck cancer. Arch Otolaryngol Head Neck Surg 2000;126(5):652- 657.