Basurto L, Saucedo R, Galván R, Vargas C, Córdova N, Campos S, Vega S, Moreno E, Avelar F, Zárate A

Language: Spanish
References: 15
Page: 13-16
PDF size: 42.49 Kb.

ABSTRACT

Objective: to determine the relationship between serum estradiol level (ESL) and testosterone serum level (TSL) with bone mineral density (BMD) in elderly men.
Methods: cross-sectional study including 127 healthy men aged 60 years and over. BMD of the lumbar spine and femoral neck were measured. ESL, TSL and sex hormone binding globulin were estimated by radioimmunoassay. Free testosterone level (FTL) was calculated.
Results: the ESL and BMD correlation at the spine was r = 0.288, (p ‹ 0.01) and at the femoral neck was r = 0.224, (p ‹ 0.01). These correlations remained significant after adjustment for BMI and age. By contrast, no correlation was found between TSL and BMD. However FTL were associated with BMD at the spine (r = 0.288, p < 0.01) and at the femoral neck (r = 0.190, p ‹ 0.05).
Conclusions: ESL and FTL are associated with BMD in elderly men. This effect may be partially mediated by the peripheral conversion of testosterone into estradiol.

REFERENCES

1. Hannan MT, Felson DT, Dawson-Hughes B, Tucker KL, Cupples LA, Wilson PW, et al. Risk factors for longitudinal bone loss in elderly men and women: the Framingham Osteoporosis Study. J Bone Miner Res 2000;15(4):710-720.

2. Basurto L, Zárate A, Gómez R, Vargas C, Saucedo R, Galván R. Effect of testosterone therapy on lumbar spine and hip mineral density in elderly men. Aging Male 2008;11(3):140-145.

3. Saucedo-García RP, Fonseca-Yerena ME, Basurto- Acevedo L, Ochoa-Reséndiz R, Sánchez M, Zárate-Treviño A. Decremento en los andrógenos circulantes en el hombre durante la senescencia. Gac Med Mex 2000;136(4):335-339.

4. Feldman H, Longcope C, Derby CA, Johannes CB, Araujo AB, Coviello AD, et al. Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts Male Aging Study. J Clin Endrocrinol Metab 2002;87(2):589-598.

5. Weinstein RS, Jilka RL, Parfitt AM, Manolagas SC. The effects of androgen deficiency on murine bone remodeling and bone mineral density are mediated via cell of the osteoblastic lineage. Endocrinology 1997;138(9):4013-4021.

6. Bellido T, Jilka RL, Boyce BF, Girasole G, Broximeyer H, Dalrymple SA, et al. Regulation of interleukin- 6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor. J Clin Invest 1995; 95(6):2886-2895.

7. Szulc P, Muñoz F, Claustrat B, Garnero P, Marchand F, Duboeuf F, et al. Bioavailable estradiol may be an important determinant of osteoporosis in men: The MINOS Study. J Clin Endocrinol Metab 2001; 86(1):192-199.

8. Gennari L, Merlotti D, MartínI G, Gonnelli S, Franci B, Campagna S, et al. Longitudinal association between sex hormone levels, bone loss, and bone turnover in elderly men. J Clin Endocrinol Metab 2003;88(11):5327-5333.

9. Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 1999;84(10):3666-3672.

10. Amin S, Zhang Y, Sarwin CT, Evans SR, Hannan MT, Kiel DP, et al. Association of hypogonadism and estradiol levels with bone mineral density in elderly men from Framing Study. Ann Intern Med 2000;133(12):951-963.

11. Mellstrom D, Johnerll O, Ljunggren O, Eriksson A, Lorentzon M, Mallmin H, et al. Free testosterone is an independent predictor of BMD and prevalent fractures in elderly men: MrOS Sweden. J Bone Miner Res 2006;21(4):529-535.

12. Vanderschueren D, Vandenput L, Boonen S, Lindberg MK, Bouillon R, Ohlsson C. Androgens and bone. Endocrine Rev 2004;25(3):389-425.

13. Khosla S, Melton LJ, Riggs BL. Estrogen and the male skeleton. J Clin Endocrinol Metab 2002;87 (4):1443-1450.

14. Campusano MC, Brusco GF, Campino JC, Rodríguez PL, Arteaga UE. Comparación de distintos métodos para evaluar la función androgénica en el adulto mayor. Rev Med Chile 2006;134(9):1123- 1128.

15. Rosner W, Auchus RJ, Asís R, Sluss PM, Raff H. Position statement: Utility, limitations, and pitfalls in measuring testosterone: an Endocrine Society position statement. J Clin Endocrinol Metab 2007; 92(2):405-413.