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2012, Number 2

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Rev Hematol Mex 2012; 13 (2)

Advantages of Hematopoietic Cells Transplant in Cases of Acute Myeloid Leukaemia

Gómez-Almaguer D, Flores-Jiménez JA, Cantú-Rodríguez O, Gutiérrez-Aguirre CH

Language: Spanish
References: 33
Page: 74-79
PDF size: 82.26 Kb.


ABSTRACT

Hematopoietic stem cell transplantation in its various forms has been used as a treatment for acute myeloid leukemia principally as rescue in relapsed leukemia. Today different cytogenetic and molecular markers have allowed guide treatment for each patient in a more individualized manner. In this way it is possible to assess the risk and thus the prognosis of the patient. The long-term survival remains a challenge for clinicians with not very encouraging numbers for developing countries. The addition of medications such as all-trans retinoic acid to chemotherapy regimens has demonstrated an excellent response and cure rates in promyelocytic leukemia. The combination of cytotoxicity and graft versus leukemia effect has allowed hematopoietic stem cell transplantation to be considered as an important therapeutic resource always guided by variables such as age, clinical condition, risk group ant matched donor availability.


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