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2012, Número 2

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Rev Hematol Mex 2012; 13 (2)


Utilidad del trasplante de células hematopoyéticas en la leucemia mieloide aguda

Gómez-Almaguer D, Flores-Jiménez JA, Cantú-Rodríguez O, Gutiérrez-Aguirre CH

Idioma: Español
Referencias bibliográficas: 33
Paginas: 74-79
Archivo PDF: 82.26 Kb.


RESUMEN

El trasplante de células hematopoyéticos en sus diversas modalidades se ha utilizado como tratamiento de la leucemia mieloide aguda, sobre todo en pacientes en recaída leucémica. Hoy en día diferentes marcadores citogenéticos y moleculares han permitido orientar el tratamiento de cada paciente en forma individualizada. De esta manera es posible evaluar el riesgo y con ello el pronóstico de dicho paciente. La supervivencia a largo plazo sigue siendo un reto para el clínico con números no muy alentadores para países como el nuestro. La adición de medicamentos, como el ácido holo-transretinoico a esquemas de quimioterapia ha demostrado una excelente respuesta y tasas de curación en la leucemia promielocítica. La combinación de citotoxicidad y efecto de injerto versus leucemia han permitido al trasplante de células hematopoyéticas consolidarse como un recurso terapéutico importante, siempre orientado por variables como la edad y condición clínica del paciente, grupo de riesgo y disponibilidad de donador compatible.


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