2011, Number 3
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Rev Hematol Mex 2011; 12 (3)
Concurrent MPL515 and JAK2V617F mutations in a patient with chronic idiopathic myelofibrosis. Case report and review of the literature
Ruiz-Delgado GJ, Lutz-Presno J, Macías-Gallardo J, Ruiz-Arguelles GJ
Language: English
References: 8
Page: 138-139
PDF size: 63.73 Kb.
ABSTRACT
Here we describe the case of a patient with a myeloproliferative neoplasia consonant with myelofiobrosis who was found to display a concurrent MPL515 and JAK2V617F mutations A brief review and discussion of the literature is made.
REFERENCES
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Lippert E, Boissinot M, Kralovics R, et al. The JAK2-V617F mutation is frequently present at diagnosis in patients with essential thrombocythemia and polycythemia vera. Blood 2006;108:1865-1867.
Pardanani AD, Levine RL, Lasho T, et al. MPL 515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients. Blood 2006;108(10):3472-3476. Epub 2006 Jul 25.
Ruiz-Arguelles GJ, Garcés Eisele J, Ortiz López R, et al. Molecular characterization of chronic myeloproliferative neoplasias in Mexico. Hematology 2009;14(5):261-265.
Lasho T, Pardanani A, McClure R, et al. Concurrent MPL515 and JAK2V617F mutations in myelofibrosis: chronology of clonal emergence and changes in mutant allele burden over time. British Journal of Haematology 2006;137:683-687.
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