2010, Number 3
<< Back Next >>
Rev Hematol Mex 2010; 11 (3)
Henry G Kunkel and multiple myeloma
Palafox D, Llorente L
Language: Spanish
References: 30
Page: 146-151
PDF size: 93.72 Kb.
ABSTRACT
Multiple myeloma’s history begins in the first half of the XIX century with the description of the first patients with the disease. Since that moment, a veritable revolution took place in the fields of medicine, immunology and chemistry, which brought about the discovery of the proteins’ structure, brand new laboratory techniques and a masterly discovery by Henry Kunkel, which radically changed the prevalent conception about myeloma’s physiopathogeny. We herein present with detail the events that lead to the elucidation of the chemical structure of malignant plasma cells’ secreted proteins.
REFERENCES
Solly S. Remarks on the pathology of mollities ossium with cases. Medical and Chirurgical Transactions of London 1844;27:435-461.
Macintyre W. Case of mollities and fragilitas ossium, accompanied with urine strongly charged with animal matter. Medical and Chirurgical Transactions of London 1850;33:211-232.
Bence-Jones H. On a new substance occurring in the urine of a patient with mollities ossium. Philosophical Transactions of the Royal Society of London (Biology) 1848;55-62.
Clamp JR. Some aspects of the first recorded case of multiple myeloma. Lancet 1967;2:1354-1356.
Von Rustizky J. Multiples myelom. Deutsche Zeitschrift für Chirurgie 1873;3: 162-172.
Kyle RA. Multiple myeloma: an odyssey of discovery. Brit J Haematol 2000; 111:1035-1044.
Behring E, Kisato S. Ueber das Zustandekommen der Diphtherie-Immunität und der Tetanus-Immunität bei Thieren. Deutsche Medicinische Wochenschrift 1890;49:1113-1114.
Ehrlich P. Experimentelle Untersuchungen ubre Immunitat. II. Ueber Abrin. Deutsch Med Wochenschr 1891;17:1218.
Ehrlich P. On immunity with special reference to cell life. Proc Roy Soc (London) 1900;66:424-448.
Arrhenius S. Immunochemistry. The application of the principles of physical chemistry to the study of the biological antibodies. New York: Macmillan, 1907.
Landsteiner K. The Specificity of Serological Reactions, 1936. Baltimore, MD. 1936.
Heidelberger M, Avery OT. The soluble specific substance of pneumococcus. J Exp Med 1923;38:73-79.
Marrack JR. The chemistry of antigens and antibodies. Special Report Series No. 194. Medical Researh Council, London, 1934.
Svedberg T, Rinde H. The ultra-centrifuge, a new instrument for the determination of size and distribution of size of particle in amicroscopic colloids. J Amer Chem Soc 1924;46:2677-2793.
Tiselius A. A new apparatus for electrophoretic analysis of colloidal mixtures. Transactions of the Faraday Society 1937;33:524.
Tiselius A, Kabat EA. An electrophoretic study of immune sera and purified antibody preparations. J Exp Med 1939;69:119-131.
Hoagland CL, Kunkel HG, Shank RE. An analysis of the effect of fat in the diet on recovery in infectious hepatitis. Am J Public Health 1946;36:1287-1292.
Kunkel HG, Hoagland CL. Persistence of elevated values for the thymol turbidity test following infectious hepatitis. Proc Soc Exp Biol Med 1946;62:258-261.
Kunkel HG, Ward SM. Plasma esterase activity in patients with liver disease and the nephrotic syndrome. J Exp Med 1947;86:325-337.
Ahrens EH, Kunkel HG. The relationship between serum lipids and skin xanthomata in eighteen patients with primary biliary cirrhosis. J Clin Invest 1949;28:1565-1574.
Kunkel HG, Slater R. Zone electrophoresis in a starch supporting medium. Proc Soc Exp Biol Med 1952;80:42-44.
Kunkel HG, Slater R, Good RA. Relation between certain myeloma proteins and normal gamma globulin. Proc Soc Exp Biol Med 1951;76:190-193.
Slater RJ, Ward SM, Kunkel HG. Immunological relationships among the myeloma proteins. J Exp Med 1955;101:85-108.
Edelman GM. Dissociation of g-globulin. J Am Chem Soc 1959;81:3155.
Edelman GM, Poulik MD. Studies on structural units of the g-globulins. J Exp Med 1961;113:861-884.
Edelman GM, Gally JA. The nature of Bence-Jones proteins. Chemical similarities to polypeptide chains of myeloma globulins and normal gamma-globulins. J Exp Med 1962;116:207-227.
Kunkel HG, Mannik M, Williams RC. Individual antigenic specificity of isolated antibodies. Science 1963;140;1218-1219.
Burnet FM. The clonal selection theory of acquired immunity. Vanderbilt University Press and Cambridge University Press, 1959.
Jerne NK. Towards a network theory of the immune system. Ann Immunol (Inst. Pasteur)1974;125C:373-389.
Khöler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 1975;256:495-497.