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Órgano Oficial del Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz

2012, Number 4

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Salud Mental 2012; 35 (4)

Neuromodulación e histamina: regulación de la liberación de neurotransmisores por receptores H3

Aquino-Miranda G, Arias-Montaño José-Antonio

Language: Spanish
References: 92
Page: 345-352
PDF size: 322.54 Kb.


ABSTRACT

Histamine regulates at the pre- and post-synaptic levels several functions of the mammalian Nervous System, in which three (H1, H2, and H3) out of the four G protein-coupled histamine receptors cloned so far are widely distributed. The histamine H3 receptor (H3R) was first identified as an auto-receptor controlling histamine synthesis and release, but several lines of evidence have shown the H3R to regulate as a hetero-receptor the release of a number of neuroactive substances, namely acetylcholine, 5-hydroxytryptamine (5-HT, serotonin), noradrenaline, dopamine, glutamate, γ-aminobutyric acid (GABA) and the neuropeptides sustance P and calcitonin gene-related peptide (CGRP). H3R-mediated regulation of the release of these neurotransmitters and neuromodulators, both in normal and pathological conditions, suggest that drugs acting at the receptor may have therapeutic use in a number of diseases such as sleep disorders, ischemia-induced cardiac arrhythmias, migraine, obesity, Alzheimer’s disease and schizophrenia.


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